ID   F16PC_LACP3             Reviewed;         643 AA.
AC   Q036S2;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=LSEI_2045;
OS   Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 /
OS   CIP 107868 / KCTC 3260 / NRRL B-441) (Lactobacillus paracasei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=321967;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL
RC   B-441;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CP000423; ABJ70800.1; -; Genomic_DNA.
DR   RefSeq; WP_011674732.1; NC_008526.1.
DR   RefSeq; YP_807242.1; NC_008526.1.
DR   AlphaFoldDB; Q036S2; -.
DR   STRING; 321967.LSEI_2045; -.
DR   EnsemblBacteria; ABJ70800; ABJ70800; LSEI_2045.
DR   KEGG; lca:LSEI_2045; -.
DR   PATRIC; fig|321967.11.peg.2008; -.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000001651; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese.
FT   CHAIN           1..643
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363094"
SQ   SEQUENCE   643 AA;  73866 MW;  40646963E148FB2B CRC64;
     MDLYSELTAK YQTVPAIATE IINLEAILNL PKPTEAFMSD IHGEYNAFQH VLRNGSGNVK
     SKIRSCFRDE MTEATLQRFA FLVYYPSERM AAIHREMAGD DLQQWYLTTF RRLIRLLAFT
     ATKYTRSKVR KAMAPEFVYI TEELLYNDAD TPDKLAYYWQ IIRNLIVLEQ ADQWIAATCQ
     TIQRLTVDHF HVVGDIYDRG PAPDQVVESL IRRDRRHSVD IQWGNHDILW IGGAAGSALC
     IANLVRISAR YNNLSILEDV YGINLRHLAR LAEQYYQDNP AFSPKMERSD RPITEAERLQ
     ITQIHQAIAM IQFKLEGPVI KRRPEFDMDH RLVLEKLAPD FSTIKLNGDT YTIENGCFAT
     VDPADPYKLL PEEQEVIDSL VESFTHSEKL HRHMDFLLDH GSMYLRYNRN LLLHGCVPVD
     EDGNFIGLTI KGTTYTGRQL FDMLEANLRL AYSQPTENAD LATDLMWYLW TGPNSPLFGK
     HDMTTFERYF ISDPKAHVEG RNPYYHLRKD PEFIKKILAE FVLDPEVGHV INGHTPVKKG
     TDPIMANNKM IVIDGGFSKP YQKTTGIGGY TLLDNSYGMQ LVTHQPFTTK ADAITNLTDI
     ISTRRVVETE ARRRTVAETD IGTELQDEVE VLKRRLGELR EED