ID   F16PC_OCEIH             Reviewed;         644 AA.
AC   Q8EMI3;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=OB2859;
OS   Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS   3954 / HTE831).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=221109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX   PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT   and its unexpected adaptive capabilities to extreme environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; BA000028; BAC14815.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8EMI3; -.
DR   STRING; 221109.22778546; -.
DR   EnsemblBacteria; BAC14815; BAC14815; BAC14815.
DR   KEGG; oih:OB2859; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   OrthoDB; 378029at2; -.
DR   PhylomeDB; Q8EMI3; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000000822; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..644
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363104"
SQ   SEQUENCE   644 AA;  75461 MW;  91EEB1E5355FA3C7 CRC64;
     MLEEKFLDLL AQKYDSEEKV VTEIINLEAI LDLPKGTEHF VSDLHGEYQA FQHVLRNGSG
     KVKEKIRDIF KHELSEKEIN EFATLIYYPE EKLQLIRNQF DNKQELNAWY TKTIDQMIRL
     IPYASSKYTR TKLRKALPKQ FVYIIEELLY KTDEYTNKKH YYSKIVQKVI SLGQADKLII
     GLAYTTQQLV VDHLHVVGDI YDRGPEPDKI MEALINYHSL DIQWGNHDVL WIGAFSGSKV
     CLANILRICA RYDNLDIIED VYGINLRPLL NLAEKYYKDN PAFRPKRHSN KKLSDQEQSQ
     ITKIHQAIAM IQFKLEMPII KRRPYFNMSK RLLLEKVDYE NNKITIDGKT YPLENTCFAT
     VNPDQPDELL EEEKQVMDKL LFSVQHSEKL ARHMEFLMKK GTLYLRYNGN LLIHGCIPID
     ENGNMEKMFI ENKTYAGREL LDIFENYLLH AFSNREATDD LATDMVWYLW TGEYSSLFGK
     REMTTFERYF IKDKALHKER KNPYYYLREK EGICRMILEE FDLDPDQGHI INGHTPVKEI
     EGENPIKANG KMIVIDGGFS KAYQPTTGIA GYTLLYNSFG MQLVAHQHFN SKEDVLQNGN
     DVLSVKRLVD EELERKKISE TNIGEKLIED INMLNSLLKY RYLK