ID   F16PC_PARD8             Reviewed;         666 AA.
AC   A6LI52;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=BDI_3671;
OS   Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM
OS   5825 / NCTC 11152).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Tannerellaceae;
OC   Parabacteroides.
OX   NCBI_TaxID=435591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152;
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CP000140; ABR45366.1; -; Genomic_DNA.
DR   RefSeq; WP_005859099.1; NC_009615.1.
DR   AlphaFoldDB; A6LI52; -.
DR   STRING; 435591.BDI_3671; -.
DR   EnsemblBacteria; ABR45366; ABR45366; BDI_3671.
DR   KEGG; pdi:BDI_3671; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_10; -.
DR   OMA; AKMHKAI; -.
DR   OrthoDB; 378029at2; -.
DR   BioCyc; PDIS435591:G1G5A-3766-MON; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000000566; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..666
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363105"
SQ   SEQUENCE   666 AA;  76678 MW;  7FFDA58931DB4AC7 CRC64;
     MTKDIIAESV QNDLRYLQLL ARSFPTIADA STEIINLEAI LNLPKGTEHF LSDLHGEDQA
     FSHVLRNASG AVKRKVNEIF SNTLRESEKK ELCSLIYYPE DKLELIKSQE QDLEDWYQVT
     LNQLVRVCRN VSSKYTRSKV RKALPKEFSY IIQELLHESS VEPNKSAYVD QIICTIISTG
     RADDFIIAMC NLIQRLTIDL LHIIGDIYDR GPGAHLIMDI LCDYHNFDVQ WGNHDILWMG
     AASGNLVSIA NVIRMCLRFG NMATLEDGYG INLLPLATFA MEAYGDDPCA LFMPKTKFAD
     NAMDEKTTRL IAQMHKAITI IQFKLEGEII RRRPEFEMDD RMLLHHIDLK RGVVHIDGKD
     YTLKDTNWPT LDPKDPYRLS IEEEDLIRKI LHSFESSEKM KKHMRCFFRH GGMYQVCNSN
     LLFHASIPMN PDGTFKSVRI LGQDYKGRAL LDRVDQLIRT AYFKTGEQEE VEYAHDYIWY
     LWGGKDSPLF DKSKMATFER AFIEEAETHK EEKGAYYTLR EQEEICDKIL DEFGVTGMHR
     HIINGHVPVR SNQGENPIKA NGKMLVIDGG FSRPYHLETG IAGYTLVYHS RGFQLVQHEP
     FESRAKAIEE GLDIKSTTIV VELSSHRQMV KDTDKGADLQ SQIKDLEKLL YAYRNGLIKE
     KERMER