ID   F16PC_PEDPA             Reviewed;         638 AA.
AC   Q03HS1;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=PEPE_0144;
OS   Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 /
OS   183-1w).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Pediococcus.
OX   NCBI_TaxID=278197;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CP000422; ABJ67251.1; -; Genomic_DNA.
DR   RefSeq; WP_002834296.1; NC_008525.1.
DR   AlphaFoldDB; Q03HS1; -.
DR   STRING; 278197.PEPE_0144; -.
DR   PRIDE; Q03HS1; -.
DR   EnsemblBacteria; ABJ67251; ABJ67251; PEPE_0144.
DR   GeneID; 33062257; -.
DR   KEGG; ppe:PEPE_0144; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; GFQIVTH; -.
DR   OrthoDB; 378029at2; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000000773; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..638
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363106"
SQ   SEQUENCE   638 AA;  73808 MW;  48E317B1976CE048 CRC64;
     MYKEKYFEEL KKEFNSEDEI VTEIVNLEAI LNLPKGTEYF ISDIHGEYDG LNHILKTGAG
     IIREKINDCF PEMNETEKNE LNFTVAYPKY ALEKRQLEQD AEELTQWYFG MITRMIGLTQ
     FCASKYSRSK VRKSLPPKYA YIIEELLYVE GSPKNKQKYY EQIISKIIEL DRAQDLIQSL
     AGTIQKMVID HIHIVGDVFD RGRKSNQVLE LLEHAHSLDF QWGNHDVLWL GGYAGSQACI
     ATLFRIATRY GYIYDLEREY GINLRALFTF ATQHYQANPA FYPKAGDFDQ NNLDLLSQVH
     QALTIIQFKL EGQVIKRQPE FQMDDRLFLD EVQQGKIQLG DQEYPLENGC FQMVDADHPY
     ELTKEEQEVI DSLSYSFRHS PKIKVHVNFI LEKGSMYLIY NNNLLYHGCI PLTEDGDFDQ
     FEYHGQKYAG KDLLTFFERH IRAGAAKKTS DEDDDTDLMW YCWIGKKSPL FGRTAMTTFE
     RYFIADSATH KEGDNPYFKL RDRLSTAHYI LRKFGLDERN SYIINGHTPV KVSEGESPIK
     GGGQIIVIDG GLSKAYQKST GIAGYTLINN SYGFQIVTHM PFQGIDDLYE SQTQSTSLKR
     IIDRDLPRRN IADTTIGTEL KRQVDDLKYL LETDEISH