ID   F16PC_PHOV8             Reviewed;         666 AA.
AC   A6L4C6;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=BVU_2901;
OS   Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS   NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Phocaeicola.
OX   NCBI_TaxID=435590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC
RC   11154;
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CP000139; ABR40540.1; -; Genomic_DNA.
DR   RefSeq; WP_005844705.1; NC_009614.1.
DR   AlphaFoldDB; A6L4C6; -.
DR   STRING; 435590.BVU_2901; -.
DR   PRIDE; A6L4C6; -.
DR   EnsemblBacteria; ABR40540; ABR40540; BVU_2901.
DR   KEGG; bvu:BVU_2901; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_10; -.
DR   OMA; AKMHKAI; -.
DR   OrthoDB; 378029at2; -.
DR   BioCyc; BVUL435590:G1G59-3021-MON; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000002861; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..666
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363076"
SQ   SEQUENCE   666 AA;  76558 MW;  3DF63C814B6195F0 CRC64;
     MNAYNSITPE TIQEDMRYLQ LLSHSFPTIA DASTEIINLE AILNLPKGTE HFLADLHGEY
     EAFQHVLRNA SGAIKRKVNE IFGNTLRENE KKELCTLIYY PEQKLDLVKA VETDLDDWYV
     ITLNQLVRVC QNVSSKYTRS KVRKSLPKEF SYIIQELLHE NSMVPNKQAY INVIISTIIS
     TRRADDFIIA LCNLIQRLTI DTLHVLGDIF DRGPAPHRIM DILCDYHNFD VQWGNHDILW
     MGAAAGNDCC MANVLRLAMR YGNLAALEDG YGINLLPLAT FAMETYADDP CTLFGPKVEK
     EDCTYNAKTL RMIGQMHKAI SVIQFKLEAE IIRRRPDFEM DDRMLLHRID FERKTITMPN
     GKEYELKDSF LPTVNPADPY KLTDEEREIM NKLHRSFVSS EKLKKHIRCL FRYGCMYTVS
     NSNLLFHASI PLNADGTLKD VSIAGKMYKG KALLEKVGHL IRTAFFAEED NEDRPFAVDY
     VWYLWCGKDS PAFDKDKMAT FERYFLKEKE LHKEVKGHYY SLRNEEKVCD MLLDEFGVIG
     THRHIINGHV PVKTIQGENP IKANGKMMVI DGGFSKAYHS ETGIAGYTLV YHSRGFQLVQ
     HEPFTSMQKA IEEGQDIKSS TQIVEMSTQR MMVKDTDKGR ELVTQINDLK KLLMAYRTGL
     IKEKSI