ID   F16PC_STAAB             Reviewed;         654 AA.
AC   Q2YW94;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=SAB2390;
OS   Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=273036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bovine RF122 / ET3-1;
RX   PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA   Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT   "Molecular correlates of host specialization in Staphylococcus aureus.";
RL   PLoS ONE 2:E1120-E1120(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; AJ938182; CAI82078.1; -; Genomic_DNA.
DR   RefSeq; WP_000192188.1; NC_007622.1.
DR   AlphaFoldDB; Q2YW94; -.
DR   KEGG; sab:SAB2390; -.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   UniPathway; UPA00138; -.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese.
FT   CHAIN           1..654
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000359982"
FT   REGION          288..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   654 AA;  76346 MW;  278FA42F0E6C00AE CRC64;
     MTQITERELK KKYLDLLSQR FDTPEKLATE IINLESILEL PKGTEHFVSD LHGEYEAFQH
     VLRNGSGNVR AKINDIFKDK LSTKELNDLT ALVYYPEDKL QLIKCDFQNY GQLNVWYITT
     IEHLIQLIKY CSSKYTRSKL RRALPEQYVF IVEELLYKNN EFKNKKSYYE TLVNQVIELK
     QADDLIIGLA YSVQRLVVDH LHVVGDIYDR GPQPDKIMDT LINYHSLDIQ WGNHDVLWVG
     AYAGSKVCLA NLLRICARYD NLDIVEDAYG INLRPLLTLA EKYYDADNPA FKPKKRPDKH
     ERLTQREESQ ITKIHQAIAM IQFKLEIPVI KRRPNFEMDE RLVLEKVNYD TNEITVYRKT
     YPLKDTCFQT VNRDNPAELL PEEEEVMNKL LLSFQQSEKL RRHMSFLMRK GSLYLPCNGN
     LLIHGCIPVD ENGEMESFEI DGQTYSGQEL LDVFEYHVRK SFDEKENTDD LSTDLVWYLW
     TGKYSSLFGK RAMTTFERYF IADKASHKEE KNPYYHLRED VNMVRKMLSD FGLNPDEGRI
     INGHTPVKEI NGEDPIKADG KMLVIDGGFS KAYQSTTGIA GYTLLYNSFG MQLVAHQQFN
     AKEKILSEGI EELSIKRIVD KELQRKKIRN TNKGKELQAQ IDILKMLMHD RYLD