ID   F16PC_STAAC             Reviewed;         654 AA.
AC   Q5HD37;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=SACOL2527;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CP000046; AAW37304.1; -; Genomic_DNA.
DR   RefSeq; WP_000192168.1; NC_002951.2.
DR   AlphaFoldDB; Q5HD37; -.
DR   EnsemblBacteria; AAW37304; AAW37304; SACOL2527.
DR   KEGG; sac:SACOL2527; -.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese.
FT   CHAIN           1..654
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000359983"
FT   REGION          288..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   654 AA;  76175 MW;  B05A7CCD3485088B CRC64;
     MTQITEKELK KKYLDLLSQN FDTPEKLATE IINLESILEL PKGTEHFVSD LHGEYEAFQH
     VLRNGSGNVR AKINDIFKER LSTKELNDLT ALVYYPEDKL KLIKSDFQNC GQLNVWYITT
     IEHLIELIKY CSSKYTRSKL RKALPKQYVY IIEELLYKSN EYQNKKSYYE TLVNQVIELK
     QADDLIIGLA YSVQRLVVDH LHVVGDIYDR GPQPDKIMDT LINYHSLDIQ WGNHDVLWVG
     AYAGSKVCLA NLLRICARYD NLDIIEDAYG INLRPLLTLA EKYYDADNPA FKPKKRPDKH
     ERLTQREESQ ITKIHQAIAM IQFKLEIPII KRRPNFEMEE RLVLEKVNYD TNEITVYGNT
     YPLKDTCFQT VNRDNPAELL PEEEEVMNKL LLSFQQSEKL RRHMSFLMRK GSLYLPYNGN
     LLIHGCIPVD ENGEMESFEI DGHTYSGQEL LDVFEYHVRK SFDEKENTDD LSTDLVWYLW
     TGKYSSLFGK RAMTTFERYF IADKASHKEE KNPYYHLRED VNMVRKMLSD FGLNPDEGRI
     INGHTPVKEI NGEDPIKADG KMLVIDGGFS KAYQSTTGIA GYTLLYNSFG MQLVAHQQFN
     AKEKILSEGI DELSIKRVVD KELQRKKIRD TNIGKDLQAQ IDILKMLMHD RYLD