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F16PC_STAAE
ID   F16PC_STAAE             Reviewed;         654 AA.
AC   A6QK04;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=NWMN_2414;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; AP009351; BAF68686.1; -; Genomic_DNA.
DR   RefSeq; WP_000192168.1; NZ_CP023390.1.
DR   AlphaFoldDB; A6QK04; -.
DR   EnsemblBacteria; BAF68686; BAF68686; NWMN_2414.
DR   KEGG; sae:NWMN_2414; -.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese.
FT   CHAIN           1..654
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000359993"
FT   REGION          288..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   654 AA;  76175 MW;  B05A7CCD3485088B CRC64;
     MTQITEKELK KKYLDLLSQN FDTPEKLATE IINLESILEL PKGTEHFVSD LHGEYEAFQH
     VLRNGSGNVR AKINDIFKER LSTKELNDLT ALVYYPEDKL KLIKSDFQNC GQLNVWYITT
     IEHLIELIKY CSSKYTRSKL RKALPKQYVY IIEELLYKSN EYQNKKSYYE TLVNQVIELK
     QADDLIIGLA YSVQRLVVDH LHVVGDIYDR GPQPDKIMDT LINYHSLDIQ WGNHDVLWVG
     AYAGSKVCLA NLLRICARYD NLDIIEDAYG INLRPLLTLA EKYYDADNPA FKPKKRPDKH
     ERLTQREESQ ITKIHQAIAM IQFKLEIPII KRRPNFEMEE RLVLEKVNYD TNEITVYGNT
     YPLKDTCFQT VNRDNPAELL PEEEEVMNKL LLSFQQSEKL RRHMSFLMRK GSLYLPYNGN
     LLIHGCIPVD ENGEMESFEI DGHTYSGQEL LDVFEYHVRK SFDEKENTDD LSTDLVWYLW
     TGKYSSLFGK RAMTTFERYF IADKASHKEE KNPYYHLRED VNMVRKMLSD FGLNPDEGRI
     INGHTPVKEI NGEDPIKADG KMLVIDGGFS KAYQSTTGIA GYTLLYNSFG MQLVAHQQFN
     AKEKILSEGI DELSIKRVVD KELQRKKIRD TNIGKDLQAQ IDILKMLMHD RYLD
 
 
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