F16PC_STAAR
ID F16PC_STAAR Reviewed; 654 AA.
AC Q6GDS9;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=SAR2596;
OS Staphylococcus aureus (strain MRSA252).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282458;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSA252;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_01854}.
CC -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC Rule:MF_01854}.
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DR EMBL; BX571856; CAG41576.1; -; Genomic_DNA.
DR RefSeq; WP_000192183.1; NC_002952.2.
DR AlphaFoldDB; Q6GDS9; -.
DR KEGG; sar:SAR2596; -.
DR HOGENOM; CLU_028392_2_0_9; -.
DR OMA; AKMHKAI; -.
DR OrthoDB; 378029at2; -.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000000596; Chromosome.
DR GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.21.10; -; 1.
DR HAMAP; MF_01854; FBPase_class3; 1.
DR InterPro; IPR009164; FBPtase_class3.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF06874; FBPase_2; 1.
DR PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR SUPFAM; SSF56300; SSF56300; 2.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Hydrolase; Manganese.
FT CHAIN 1..654
FT /note="Fructose-1,6-bisphosphatase class 3"
FT /id="PRO_0000359986"
FT REGION 288..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 654 AA; 76213 MW; D6D4337D6C40E585 CRC64;
MTQITERELK KKYLDLLSQH FDTPEKLATE IINLESILEL PKGTEHFVSD LHGEYEAFQH
VLRNGSGNVR AKINDIFKDK LSTKELNDLT ALVYYPEDKL QLIKCDFQNY GQLNVWYITT
IEHLIQLIKY CSSKYTRSKL RRALPEQYVF IVEELLYKNN EFKNKKSYYE TLVNQVIELK
QADDLIIGLA YSVQRLVVDH LHVVGDIYDR GPQPDKIMDT LINYHSLDIQ WGNHDVLWVG
AYAGSKVCLA NLLRICARYD NLDIVEDAYG INLRPLLTLA EKYYDADNPA FKPKKRPDKH
ERLTQREESQ ITKIHQAIAM IQFKLEIPVI KRRPNFEMDE RLVLEKVNYD TNEITVYGKT
YPLKDTCFQT VNRDNPAKLL PEEEEVMNKL LLSFQQSEKL RRHMSFLMRK GSLYLPCNGN
LLIHGCIPVD ENGEMESFEI DGQTYSGQEL LDVFEYHVRK SFDEKENTDD LSTDLVWYLW
TGKYSSLFGK RAMTTFERYF IADKASHKEE KNPYYHLRED VNMVRKMLSD FGLNPDEGRI
INGHTPVKEI NGEDPIKADG KMLVIDGGFS KAYQSTTGIA GYTLLYNSFG MQLVAHQQFN
AKEKILSEGI DELSIKRIVD KELQRKKIRN TNKGKELQAQ IDILKMLMHD RYLD