F16PC_STAAT
ID F16PC_STAAT Reviewed; 654 AA.
AC A8Z3B1;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854};
GN OrderedLocusNames=USA300HOU_2505;
OS Staphylococcus aureus (strain USA300 / TCH1516).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=451516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300 / TCH1516;
RX PubMed=17986343; DOI=10.1186/1471-2180-7-99;
RA Highlander S.K., Hulten K.G., Qin X., Jiang H., Yerrapragada S.,
RA Mason E.O. Jr., Shang Y., Williams T.M., Fortunov R.M., Liu Y., Igboeli O.,
RA Petrosino J., Tirumalai M., Uzman A., Fox G.E., Cardenas A.M., Muzny D.M.,
RA Hemphill L., Ding Y., Dugan S., Blyth P.R., Buhay C.J., Dinh H.H.,
RA Hawes A.C., Holder M., Kovar C.L., Lee S.L., Liu W., Nazareth L.V.,
RA Wang Q., Zhou J., Kaplan S.L., Weinstock G.M.;
RT "Subtle genetic changes enhance virulence of methicillin resistant and
RT sensitive Staphylococcus aureus.";
RL BMC Microbiol. 7:99-99(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_01854}.
CC -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC Rule:MF_01854}.
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DR EMBL; CP000730; ABX30491.1; -; Genomic_DNA.
DR RefSeq; WP_000192168.1; NC_010079.1.
DR AlphaFoldDB; A8Z3B1; -.
DR KEGG; sax:USA300HOU_2505; -.
DR HOGENOM; CLU_028392_2_0_9; -.
DR OMA; AKMHKAI; -.
DR UniPathway; UPA00138; -.
DR GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.21.10; -; 1.
DR HAMAP; MF_01854; FBPase_class3; 1.
DR InterPro; IPR009164; FBPtase_class3.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF06874; FBPase_2; 1.
DR PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR SUPFAM; SSF56300; SSF56300; 2.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Hydrolase; Manganese.
FT CHAIN 1..654
FT /note="Fructose-1,6-bisphosphatase class 3"
FT /id="PRO_0000359994"
FT REGION 288..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 654 AA; 76175 MW; B05A7CCD3485088B CRC64;
MTQITEKELK KKYLDLLSQN FDTPEKLATE IINLESILEL PKGTEHFVSD LHGEYEAFQH
VLRNGSGNVR AKINDIFKER LSTKELNDLT ALVYYPEDKL KLIKSDFQNC GQLNVWYITT
IEHLIELIKY CSSKYTRSKL RKALPKQYVY IIEELLYKSN EYQNKKSYYE TLVNQVIELK
QADDLIIGLA YSVQRLVVDH LHVVGDIYDR GPQPDKIMDT LINYHSLDIQ WGNHDVLWVG
AYAGSKVCLA NLLRICARYD NLDIIEDAYG INLRPLLTLA EKYYDADNPA FKPKKRPDKH
ERLTQREESQ ITKIHQAIAM IQFKLEIPII KRRPNFEMEE RLVLEKVNYD TNEITVYGNT
YPLKDTCFQT VNRDNPAELL PEEEEVMNKL LLSFQQSEKL RRHMSFLMRK GSLYLPYNGN
LLIHGCIPVD ENGEMESFEI DGHTYSGQEL LDVFEYHVRK SFDEKENTDD LSTDLVWYLW
TGKYSSLFGK RAMTTFERYF IADKASHKEE KNPYYHLRED VNMVRKMLSD FGLNPDEGRI
INGHTPVKEI NGEDPIKADG KMLVIDGGFS KAYQSTTGIA GYTLLYNSFG MQLVAHQQFN
AKEKILSEGI DELSIKRVVD KELQRKKIRD TNIGKDLQAQ IDILKMLMHD RYLD
