ID   F16PC_STAES             Reviewed;         654 AA.
AC   Q8CN27;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=SE_2063;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; AE015929; AAO05704.1; -; Genomic_DNA.
DR   RefSeq; NP_765618.1; NC_004461.1.
DR   RefSeq; WP_002438166.1; NZ_WBME01000003.1.
DR   AlphaFoldDB; Q8CN27; -.
DR   STRING; 176280.SE_2063; -.
DR   EnsemblBacteria; AAO05704; AAO05704; SE_2063.
DR   GeneID; 50017850; -.
DR   KEGG; sep:SE_2063; -.
DR   PATRIC; fig|176280.10.peg.2016; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese.
FT   CHAIN           1..654
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000359996"
SQ   SEQUENCE   654 AA;  76313 MW;  40F1F2631C9541FF CRC64;
     MTHITESEMK QKYLDLLSQK FDSAEKLATE IINLESILEL PKGTEHFVSD LHGEYESFQH
     VLRNGSGNVR AKINDIFKDK LSQQEINDLA ALVYYPEEKL KLVKNNFDSI GTLNIWYITT
     IQRLIDLITY CSSKYTRSKL RKALPEQYVY IIEELLYKSN EFHNKKPYYE TLVNQIIELE
     QSDDLIIGLS YTVQRLVVDH LHVVGDIYDR GPKPDKIMDT LINYHSVDIQ WGNHDVLWIG
     AYAGSKVCLA NLLRICARYD NLDIIEDAYG INLRPLLTLA EKYYDAENPA FKPKKRPDKD
     VSLTKREESQ ITKIHQAIAM IQFKLEMPII KRRPSFEMEE RLVLEKIDYD NNEITIYNKT
     YPLKDTCFQT VNPNNPAELL AEEKEVMDKL LLSFQQSEKL RRHMSFLMRK GKLYLPYNGN
     LLIHGCIPVD ENGEMESFEI EGERLSGREL LDVFEYHVRR AFDHKESTED ISTDLVWYLW
     TGKYSSLFGK RAMTTFERYF IEDKASHKEE KNPYYYLRED VDMIRKMLKD FGLNPDEGRI
     INGHTPVKEI DGEDPIKANG KMLVIDGGFS KAYQSTTGIA GYTLLYNSFG MQLVAHKEFN
     RKEKVLSMGA DELSVKRVVD EELQRKKIRD TNIGKQLQDQ IDILKILMHD RYLT