F16PC_STAS1
ID F16PC_STAS1 Reviewed; 650 AA.
AC Q4A071;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=SSP0398;
OS Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS 20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=342451;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT pathogenesis of uncomplicated urinary tract infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_01854}.
CC -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC Rule:MF_01854}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP008934; BAE17543.1; -; Genomic_DNA.
DR RefSeq; WP_011302371.1; NZ_MTGA01000036.1.
DR AlphaFoldDB; Q4A071; -.
DR STRING; 342451.SSP0398; -.
DR EnsemblBacteria; BAE17543; BAE17543; SSP0398.
DR KEGG; ssp:SSP0398; -.
DR PATRIC; fig|342451.11.peg.403; -.
DR eggNOG; COG3855; Bacteria.
DR HOGENOM; CLU_028392_2_0_9; -.
DR OMA; AKMHKAI; -.
DR OrthoDB; 378029at2; -.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000006371; Chromosome.
DR GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.21.10; -; 1.
DR HAMAP; MF_01854; FBPase_class3; 1.
DR InterPro; IPR009164; FBPtase_class3.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF06874; FBPase_2; 1.
DR PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR SUPFAM; SSF56300; SSF56300; 2.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT CHAIN 1..650
FT /note="Fructose-1,6-bisphosphatase class 3"
FT /id="PRO_0000359999"
SQ SEQUENCE 650 AA; 75445 MW; 4EF7098F86B0ED46 CRC64;
MQKSADKSLK DRYLDLLSQQ FNTKEELATE IINLESILEL PKGTEHFVSD LHGEFHAFQH
VLRNGSGNVR SKINDIFQDT LTRKEINEFS ALVYYPEEKL KIIKNSFSSK SELNEWYITT
INRLIKLITY ASSKYTRTKL RKSLPKNYVF IIEELLYKSN KYNNKHSYYE TLINQIIELE
QSDDLIIGLS FTVQHLVVDH LHVVGDIYDR GPEPDKIMET LIDYPSVDIQ WGNHDVLWIG
AYAGSKVCLA NLLRICARYD NLDIIEDAYG INLRPLLTLA EKHYDGKNKA FRPKNAEGLT
ELELEQITKI HQAIAIIQFK LEAPIIKRRP TFEMEERLVL ESINYEKNEA TLYGKTYPLE
NTCFQTIDPN GPNKLTDEES EVMDKLLLSV QQSEKLKRHM TFLMQKGTLY LPYNGNLLIH
GCIPVDENGE MESMVINDVK CYGRDLLDHF EDYVREAFDH KDIQDDLATD LVWYLWTGKY
SSLFGKRAMT TFERYFIKDK TAHKETKNPY YHLREDVNMC KKMLKDFGLD PEQGHIINGH
TPVKEIDGED PIKAEGKMIV IDGGFSKAYQ STTGIAGYTL LYNSFGMQLV AHQHFNSKKH
VLLNGADELS IRRVVDKELQ RQKIRHTNTG QDIQEKIDIL KELMHDRYVN
