ID   F16PC_STAXY             Reviewed;         650 AA.
AC   A0SJA5;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854};
OS   Staphylococcus xylosus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1288;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 20267 / Isolate C2A;
RX   PubMed=17233729; DOI=10.1111/j.1574-6968.2006.00538.x;
RA   Dordet-Frisoni E., Talon R., Leroy S.;
RT   "Physical and genetic map of the Staphylococcus xylosus C2a chromosome.";
RL   FEMS Microbiol. Lett. 266:184-193(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; DQ472006; ABF13435.1; -; Genomic_DNA.
DR   RefSeq; WP_047171898.1; NZ_LN554884.1.
DR   AlphaFoldDB; A0SJA5; -.
DR   STRING; 1288.SXYLSMQ121_0420; -.
DR   KEGG; sxo:SXYL_00426; -.
DR   eggNOG; COG3855; Bacteria.
DR   UniPathway; UPA00138; -.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese.
FT   CHAIN           1..650
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363111"
SQ   SEQUENCE   650 AA;  75278 MW;  D444C4CAB2326C64 CRC64;
     MHNSTDKSVK ERFLDLLSEQ FNTKEALATE IINLESILEL PKGTEHFVSD LHGEFHSFQH
     VLRNGSGNVR SKINDIFQDT LTRKEINEFS ALVYYPEEKL QLIKNSFSSK SELNEWYITT
     INRLIKLITY ASSKYTRTKL RKSLPENYVF IVEELLYKSN KYNNKHSYYE TLIKQIIELE
     QSDDLIIGLS FTVQHLVVNH LHVVGDIYDR GPEPDKIMET LIDYPSVDIQ WGNHDVLWIG
     AYAGSKVCLA NLLRICARYD NLDIIEDAYG INLRPLLTLA DKYYDGSNPA FRPKNAEGLS
     ELELEQITKL HQAIAIIQFK LEAPIIKRRP AFEMEERLVL EKIDYDKNEA TLYGKTYPLE
     HTCFQTVDPN DPNKLTDEEA DVIDKLLLSV QQSEKLKRHM TFLMQKGKLY LPYNGNLLIH
     GCIPVDEQGE MESMVIDGVK CYGRDLLDHF EEYVRIAFDH KDIQDDLATD LVWYLWTGKY
     SSLFGKRAMT TFERYFIKDK TAHKETKNPY YYLREDVDMC KKMLKDFGLD PEQGHIINGH
     TPVKEIDGED PIKADGKMIV IDGGFSKAYQ STTGIAGYTL LYNSFGMQLV AHQHFNSKKH
     VLLNGADELS IRRVVDKELQ RKKIRDTNTG HEIQAQIDIL KELMHDRFVN