ID   F16PC_STRA5             Reviewed;         643 AA.
AC   Q8E146;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=SAG0516;
OS   Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=208435;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-611 / 2603 V/R;
RX   PubMed=12200547; DOI=10.1073/pnas.182380799;
RA   Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N.,
RA   Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D.,
RA   Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA   DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Lewis M.R., Radune D.,
RA   Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A.,
RA   Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T.,
RA   Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D.,
RA   Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M.;
RT   "Complete genome sequence and comparative genomic analysis of an emerging
RT   human pathogen, serotype V Streptococcus agalactiae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; AE009948; AAM99418.1; -; Genomic_DNA.
DR   RefSeq; NP_687546.1; NC_004116.1.
DR   RefSeq; WP_000064640.1; NC_004116.1.
DR   AlphaFoldDB; Q8E146; -.
DR   STRING; 208435.SAG0516; -.
DR   EnsemblBacteria; AAM99418; AAM99418; SAG0516.
DR   KEGG; sag:SAG0516; -.
DR   PATRIC; fig|208435.3.peg.513; -.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000000821; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..643
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363114"
SQ   SEQUENCE   643 AA;  74921 MW;  F687C2C2453BE4DA CRC64;
     MSNFYKLLKE KFPRKEDIVT EMINLEAICQ LPKGTEYFIS DLHGEYDAVD YLLRTGAGSI
     RAKLLDCFDW QKIVAVDLDD FCILLYYPKE KLAFDKMNLS ASAYKTKLWE MIPLQIQVLK
     YFSSKYTKSK VRKQLSGKFA YIIEELLAEI DRNPEKKSYF DTIIEKLFEL DQVEDLIIVL
     SQTIQVLIID HLHVVGDIYD RGRYPDRILN RLMAFPNLDI QWGNHDVTWM GAASGSYLCM
     VNVIRIAARY NNITLIEDRY GINLRRLVDY SRRYYEPLPS FVPILDGEEM THPDELDLLN
     MIQQATAILQ FKLEAQLIDR RPEFQMHNRQ LINQVNYKDL SISIKEVVHQ LKDFNSRCID
     SKNPSRLTSE EEELLQQLMI AFQTSESLKK HIDFLFEKGS MYLTYNDNLL FHGCIPMHSN
     GDFKSFKIAG KTYGGRDLLD LFESQIRLAY ARPEKHDDLA TDIIWYLWCG ENSSLFGKNA
     MTTFERYYVS DKVTHQERKN PYFKLRDKDD ICTALLQEFD LPKFGHIVNG HTPVKEKNGE
     QPIKANGKML VIDGGFAKGY QKNTGLAGYT LIYNSYGIQL ISHLPFTSIE EVLSGTNYII
     DTKRLVEEAK DRILVKDTTI GQKLTKEIKD LDHLYRHFQE YDD