ID   F16PC_STRGC             Reviewed;         636 AA.
AC   A8AWF2;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=SGO_0813;
OS   Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 /
OS   DL1 / V288).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=467705;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288;
RX   PubMed=17720781; DOI=10.1128/jb.01023-07;
RA   Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.;
RT   "Genome-wide transcriptional changes in Streptococcus gordonii in response
RT   to competence signaling peptide.";
RL   J. Bacteriol. 189:7799-7807(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; CP000725; ABV09406.1; -; Genomic_DNA.
DR   RefSeq; WP_012000272.1; NC_009785.1.
DR   AlphaFoldDB; A8AWF2; -.
DR   STRING; 467705.SGO_0813; -.
DR   EnsemblBacteria; ABV09406; ABV09406; SGO_0813.
DR   KEGG; sgo:SGO_0813; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; GFQIVTH; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000001131; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   SUPFAM; SSF56300; SSF56300; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..636
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363115"
SQ   SEQUENCE   636 AA;  73172 MW;  CF41E2D1A30A60AD CRC64;
     MEQYKRILLK EFDSRQKVIT ELTNLEAILN LPKGTELYIS DIHGEFEAFD YILRSCAGIL
     NEKIKDCFGD SLSQDDKNRL SALVSYPELV LKEGNKSRDW YKDTIPQLLS LLAFAAAKYS
     RSKLRKALPP QYAYIIEELV YSDTALADKK SYFENILSYV IELREAVPFI LGISGSIRRL
     LIDHLHVVGD IFDRGAGSPQ VMDELLHFHS LDIQWGNHDI IWMGGFFGSK ACMLNALRIA
     ARYGYLWDIE KAYGLNLRAL TLFADRTYKT NPKFRPILGH REVDFTAEEI LQLEKVHQAL
     TIIQFKLESQ LIKRRPEFQM EDQVTLDKID YWEECLTIDD KKHPLINTCF QTIDPTNPSE
     LSPEEAQAVD SMLASFQGSL KLAEHINLLM KKGSMYKIYN QHLLFHGCIP LEPSGEFQPL
     MIHQAHYVGR KLLDFFEYHI RQAAKNKEIG DDFSTDLIWY CWRGKLSPLF GKDKMTTLER
     YFIEDKETHK EVENSYFSYR NSEKICQLIL EEFGLFSQES RMVNGHTPVK TGKGESPIRG
     GGLLFVIDGG LCEAYQEKTG TAGYSLLNNS YGFQLVTHQP FQNAQKVVEA PFAQTSLKKV
     IENVEQRTLI KSTSIGQILM AQQQELFALL HEFYDF