ID   F16PC_STRSV             Reviewed;         636 AA.
AC   A3CMR5;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=SSA_1056;
OS   Streptococcus sanguinis (strain SK36).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=388919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK36;
RX   PubMed=17277061; DOI=10.1128/jb.01808-06;
RA   Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA   Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA   Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT   "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL   J. Bacteriol. 189:3166-3175(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000387; ABN44470.1; -; Genomic_DNA.
DR   RefSeq; WP_011836894.1; NC_009009.1.
DR   RefSeq; YP_001035020.1; NC_009009.1.
DR   AlphaFoldDB; A3CMR5; -.
DR   STRING; 388919.SSA_1056; -.
DR   EnsemblBacteria; ABN44470; ABN44470; SSA_1056.
DR   KEGG; ssa:SSA_1056; -.
DR   PATRIC; fig|388919.9.peg.1002; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; GFQIVTH; -.
DR   OrthoDB; 378029at2; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000002148; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   SUPFAM; SSF56300; SSF56300; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..636
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_0000363116"
SQ   SEQUENCE   636 AA;  73073 MW;  0F815492FFCF8492 CRC64;
     MEQYKRILLK EFDSRQKVIT ELTNLEAILN LPKGTELYIS DIHGEFAAFD YILRSCAGIL
     NEKIKDCFGD SLSEVHKDRL SALVSYPELV LGEETKGQDW YQETIPQLLN LLAFAGAKYS
     RSKVRKALPP QYAYIIEELL YSDTALADKK SYFENILTYV IELREAVPFI LGLSRSIRQL
     LIDHLHVVGD IFDRGVGSAQ VIDELQHFHS LDIQWGNHDI IWMGAFFGSK ACLLNVLRIA
     ARYGYLWDIE KDYGLNLRSL TLFADKTYQS NPKFRPILGG REQEFSEEEI LQLEKVHQAL
     SIIQFKLENQ LIKRRPEFQM QDHVMLDKID YWEESITIDD TKHALVNTCF QTINPENPSA
     LTPEENQAVD SMLASFQSSL KMAEHMSLLM NKGSMYKIYN KHLLFHGCIP LEPSGEFQPF
     ILNQAHYAGK ELLDFFEYHI RQAAKDKEVG DDLSTDLIWY CWKGKLSPLF GKEKMTTLER
     YFIEDKETHK EVENSYFSYR NSEKVCQLIL EEFGLFSQES RMVNGHTPVK TGKGESPIRG
     GGLLFVIDGG LCKAYQKKTG TAGYSLLNNS YGFQLVTHQP FQNAQKVVES PFAQTSLKKV
     IENVEERTLI KSTTIGQSLL AQQQELFGLL HEFYDR