ID   F16PC_STRU0             Reviewed;         638 AA.
AC   B9DRN4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE            EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE   AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN   Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=SUB0619;
OS   Streptococcus uberis (strain ATCC BAA-854 / 0140J).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=218495;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-854 / 0140J;
RX   PubMed=19175920; DOI=10.1186/1471-2164-10-54;
RA   Ward P.N., Holden M.T.G., Leigh J.A., Lennard N., Bignell A., Barron A.,
RA   Clark L., Quail M.A., Woodward J., Barrell B.G., Egan S.A., Field T.R.,
RA   Maskell D., Kehoe M., Dowson C.G., Chanter N., Whatmore A.M., Bentley S.D.,
RA   Parkhill J.;
RT   "Evidence for niche adaptation in the genome of the bovine pathogen
RT   Streptococcus uberis.";
RL   BMC Genomics 10:54-54(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC         phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01854}.
CC   -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01854}.
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DR   EMBL; AM946015; CAR41447.1; -; Genomic_DNA.
DR   RefSeq; WP_012658140.1; NC_012004.1.
DR   AlphaFoldDB; B9DRN4; -.
DR   STRING; 218495.SUB0619; -.
DR   EnsemblBacteria; CAR41447; CAR41447; SUB0619.
DR   KEGG; sub:SUB0619; -.
DR   eggNOG; COG3855; Bacteria.
DR   HOGENOM; CLU_028392_2_0_9; -.
DR   OMA; AKMHKAI; -.
DR   OrthoDB; 378029at2; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000000449; Chromosome.
DR   GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.60.21.10; -; 1.
DR   HAMAP; MF_01854; FBPase_class3; 1.
DR   InterPro; IPR009164; FBPtase_class3.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF06874; FBPase_2; 1.
DR   PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Hydrolase; Manganese; Reference proteome.
FT   CHAIN           1..638
FT                   /note="Fructose-1,6-bisphosphatase class 3"
FT                   /id="PRO_1000188682"
SQ   SEQUENCE   638 AA;  74170 MW;  87FEC912B469CFB1 CRC64;
     MSQYFSLLKE KFPTKSSLLT EMINLDAICH LPKGTEYFLS DLHGEYQAFD YLLRNASGSI
     KKKLQECFPE KDSEDIDKLC QYIYYPSEKI AAQQEILGEK ALQEELSFYL PDLIQFVKYT
     GSKYTRSKVR KMLPADYAYI MEELLTEEQP DKNKHFYYQA ILAKVIELEQ LDNLFVAFAQ
     LIQKLSIDHL HIVGDIFDRG KYPDFILERL RSFRNIDIQW GNHDITWIGA ISGSYICMIN
     VIRIAARYNS IDLIEDRYGI NLRRLIEYSQ SHFQEEDVFN PILDGEEIAD SERMVLNQLQ
     QATALLQFKL EHQLIKRRPC FGMEAGLLFS KIDTENQTIT IGDITYPLQS FPFEMMDWDN
     PDGLTEEEEA LLKGLMYRFQ NSTLLKEHVD FLIEKGGMYH ISNNHLLFHG CMPMHSNGDF
     KSMVFGKQAY SGRALLDFFE EQVLESYKNP DSHEDFQTDI FWYLWCGEVS SLFGKDRMTT
     FERYYIADKT SHVEHKNPYY KLRENEEICL RILEEFGLDK SAHIVNGHTP VKEKGGELPI
     KANGRMIIID GGLAKGYQKT TGIAGYTLIS NSYGLELVAH KPFSSVQDVL EGKCDIIFIK
     RLVEIVENRT LVKETDNGQL LLKEIADLEY LYHHFDQF