F170B_HUMAN
ID F170B_HUMAN Reviewed; 283 AA.
AC A6NMN3; Q86WY6; Q8N6K8;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Protein FAM170B {ECO:0000305};
DE AltName: Full=Acrosome-related protein {ECO:0000303|PubMed:26179146};
GN Name=FAM170B {ECO:0000312|HGNC:HGNC:19736};
GN Synonyms=C10orf73 {ECO:0000312|HGNC:HGNC:19736};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND INTERACTION WITH GOPC.
RX PubMed=26179146; DOI=10.1002/mrd.22523;
RA Li Y., Lin S., Luo M., Guo H., Chen J., Ma Q., Gu Y., Jiang Z., Gui Y.;
RT "FAM170B, a novel acrosomal protein involved in fertilization in mice.";
RL Mol. Reprod. Dev. 82:787-796(2015).
CC -!- FUNCTION: Plays a role in fertilization through the acrosome reaction.
CC {ECO:0000250|UniProtKB:E9PXT9}.
CC -!- SUBUNIT: Interacts with GOPC. {ECO:0000269|PubMed:26179146}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC {ECO:0000269|PubMed:26179146}. Cytoplasmic vesicle, secretory vesicle,
CC acrosome outer membrane {ECO:0000250|UniProtKB:E9PXT9}.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in adult testis.
CC {ECO:0000269|PubMed:26179146}.
CC -!- SIMILARITY: Belongs to the FAM170 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH29839.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH47597.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC084727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029839; AAH29839.1; ALT_INIT; mRNA.
DR EMBL; BC047597; AAH47597.1; ALT_INIT; mRNA.
DR CCDS; CCDS53536.1; -.
DR RefSeq; NP_001157956.1; NM_001164484.1.
DR AlphaFoldDB; A6NMN3; -.
DR STRING; 9606.ENSP00000308292; -.
DR iPTMnet; A6NMN3; -.
DR PhosphoSitePlus; A6NMN3; -.
DR BioMuta; FAM170B; -.
DR MassIVE; A6NMN3; -.
DR PaxDb; A6NMN3; -.
DR PeptideAtlas; A6NMN3; -.
DR PRIDE; A6NMN3; -.
DR TopDownProteomics; A6NMN3; -.
DR Antibodypedia; 61247; 33 antibodies from 9 providers.
DR DNASU; 170370; -.
DR Ensembl; ENST00000311787.6; ENSP00000308292.6; ENSG00000172538.7.
DR GeneID; 170370; -.
DR KEGG; hsa:170370; -.
DR MANE-Select; ENST00000311787.6; ENSP00000308292.6; NM_001164484.2; NP_001157956.1.
DR UCSC; uc001jhj.4; human.
DR CTD; 170370; -.
DR GeneCards; FAM170B; -.
DR HGNC; HGNC:19736; FAM170B.
DR HPA; ENSG00000172538; Tissue enriched (testis).
DR neXtProt; NX_A6NMN3; -.
DR PharmGKB; PA162387168; -.
DR VEuPathDB; HostDB:ENSG00000172538; -.
DR eggNOG; ENOG502S6PC; Eukaryota.
DR GeneTree; ENSGT00940000162512; -.
DR HOGENOM; CLU_062038_1_0_1; -.
DR InParanoid; A6NMN3; -.
DR OMA; TELLECC; -.
DR OrthoDB; 1142827at2759; -.
DR PhylomeDB; A6NMN3; -.
DR TreeFam; TF337124; -.
DR PathwayCommons; A6NMN3; -.
DR BioGRID-ORCS; 170370; 16 hits in 1070 CRISPR screens.
DR GenomeRNAi; 170370; -.
DR Pharos; A6NMN3; Tdark.
DR PRO; PR:A6NMN3; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; A6NMN3; protein.
DR Bgee; ENSG00000172538; Expressed in left testis and 14 other tissues.
DR Genevisible; A6NMN3; HS.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:UniProtKB.
DR GO; GO:0002081; C:outer acrosomal membrane; ISS:UniProtKB.
DR GO; GO:0009566; P:fertilization; IBA:GO_Central.
DR GO; GO:2000344; P:positive regulation of acrosome reaction; ISS:UniProtKB.
DR GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR InterPro; IPR033377; FAM170B.
DR InterPro; IPR040879; Spt46-like.
DR PANTHER; PTHR33517; PTHR33517; 1.
DR PANTHER; PTHR33517:SF2; PTHR33517:SF2; 1.
DR Pfam; PF17734; Spt46; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Membrane; Reference proteome.
FT CHAIN 1..283
FT /note="Protein FAM170B"
FT /id="PRO_0000310494"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 69
FT /note="R -> L (in dbSNP:rs17773851)"
FT /id="VAR_037062"
FT CONFLICT 84
FT /note="S -> F (in Ref. 2; AAH29839)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 283 AA; 32092 MW; 4DEE3A62AF7BE9DF CRC64;
MKCYFTDHRG EQSPTDGTTL SLTSPESTEE SVEVFWPGTI QREGSSPRPG PAIPREEGLY
FAARDRGMRD WSSSPSSESS EYQSYSQYQS CCSCMCDEDN AAPQSVCAFY THVQTVRGVA
VAWETEAGFE PVTRKPRIHE AQFIKRQRWN GSSFEMASNT DMRWDLEACK SNCSPEPEDI
DLLECCLQEL REPPDWLVTT NYGVRCVACC RVLPSLDALL EHAQHGIREG FSCQIFFEEM
LERRRAQGQA HDQQLEEEQS PSDNSECSRP QGEVLSAQQQ EKQ
