F170B_MOUSE
ID F170B_MOUSE Reviewed; 378 AA.
AC E9PXT9;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Protein FAM170B {ECO:0000305};
DE AltName: Full=Acrosome-related protein {ECO:0000303|PubMed:26179146};
GN Name=Fam170b {ECO:0000312|MGI:MGI:2145650};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=26179146; DOI=10.1002/mrd.22523;
RA Li Y., Lin S., Luo M., Guo H., Chen J., Ma Q., Gu Y., Jiang Z., Gui Y.;
RT "FAM170B, a novel acrosomal protein involved in fertilization in mice.";
RL Mol. Reprod. Dev. 82:787-796(2015).
CC -!- FUNCTION: Plays a role in fertilization through the acrosome reaction.
CC {ECO:0000269|PubMed:26179146}.
CC -!- SUBUNIT: Interacts with GOPC. {ECO:0000250|UniProtKB:A6NMN3}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC {ECO:0000269|PubMed:26179146}. Cytoplasmic vesicle, secretory vesicle,
CC acrosome outer membrane {ECO:0000269|PubMed:26179146}.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in adult testis (at protein
CC level). Expression first started at postnatal week 3 in round
CC spermatids, elongated spermatids and mature sperm.
CC {ECO:0000269|PubMed:26179146}.
CC -!- SIMILARITY: Belongs to the FAM170 family. {ECO:0000305}.
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DR EMBL; AC133585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS49439.1; -.
DR RefSeq; NP_001157957.1; NM_001164485.1.
DR AlphaFoldDB; E9PXT9; -.
DR STRING; 10090.ENSMUSP00000100529; -.
DR PhosphoSitePlus; E9PXT9; -.
DR PaxDb; E9PXT9; -.
DR PRIDE; E9PXT9; -.
DR ProteomicsDB; 275509; -.
DR Antibodypedia; 61247; 33 antibodies from 9 providers.
DR Ensembl; ENSMUST00000104926; ENSMUSP00000100529; ENSMUSG00000078127.
DR GeneID; 105511; -.
DR KEGG; mmu:105511; -.
DR UCSC; uc011ziq.1; mouse.
DR CTD; 170370; -.
DR MGI; MGI:2145650; Fam170b.
DR VEuPathDB; HostDB:ENSMUSG00000078127; -.
DR eggNOG; ENOG502S6PC; Eukaryota.
DR GeneTree; ENSGT00940000162512; -.
DR HOGENOM; CLU_062038_1_0_1; -.
DR InParanoid; E9PXT9; -.
DR OMA; TELLECC; -.
DR OrthoDB; 1142827at2759; -.
DR PhylomeDB; E9PXT9; -.
DR TreeFam; TF337124; -.
DR BioGRID-ORCS; 105511; 3 hits in 74 CRISPR screens.
DR PRO; PR:E9PXT9; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; E9PXT9; protein.
DR Bgee; ENSMUSG00000078127; Expressed in spermatid and 26 other tissues.
DR Genevisible; E9PXT9; MM.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:UniProtKB.
DR GO; GO:0002081; C:outer acrosomal membrane; IDA:UniProtKB.
DR GO; GO:0009566; P:fertilization; IBA:GO_Central.
DR GO; GO:2000344; P:positive regulation of acrosome reaction; IMP:UniProtKB.
DR GO; GO:0080154; P:regulation of fertilization; IMP:UniProtKB.
DR InterPro; IPR033377; FAM170B.
DR InterPro; IPR040879; Spt46-like.
DR PANTHER; PTHR33517; PTHR33517; 1.
DR PANTHER; PTHR33517:SF2; PTHR33517:SF2; 1.
DR Pfam; PF17734; Spt46; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasmic vesicle; Membrane; Reference proteome.
FT CHAIN 1..378
FT /note="Protein FAM170B"
FT /id="PRO_0000435474"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..347
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 43766 MW; 2D8AF2CE6CB13D53 CRC64;
MKHHLIEHRG EQTPGTAVGM ASPDAAEEST GVCWPGGAMR RNESSPRPGP AFLPDDDIYL
AARAQGVLGW SSSPSSQSSS EYQSYSQYQS WDSSKSEEQQ ETPPESVCAL YTHVQTVRGV
AVAWETDDGF EPVTRKPLIR EAEFIKRQRR KGSSFEMASN TDLRWELEDC KHYCPQTEDP
VDCCMQELRA PPDWLVTTNH GLRCVACCRV FPTLEALLDH AQHGIQDGFS CQIFFEEMLE
RKRTRDQKQD QQPVEEEQSL SDSSECTRLL TKVLPWQQQP QQQPQEQQKQ QQQQQQKQRQ
QEQQQHQQQQ QQPQPLKQQQ QQQQQQPLQP QPLKQQPLQP LQPQPQPQPQ KQQQRQQQRQ
QQPPRQQQKQ QPLQQQGK
