F1712_MOUSE
ID F1712_MOUSE Reviewed; 822 AA.
AC A2A699; B7ZC48; Q05CH6; Q6P2L1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Protein FAM171A2;
DE Flags: Precursor;
GN Name=Fam171a2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-507 (ISOFORM 1).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-369; SER-371 AND SER-785, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A2A699-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2A699-2; Sequence=VSP_032783;
CC -!- SIMILARITY: Belongs to the FAM171 family. {ECO:0000305}.
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DR EMBL; AL596258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC025575; AAH25575.1; -; mRNA.
DR EMBL; BC064455; AAH64455.1; -; mRNA.
DR CCDS; CCDS36344.1; -. [A2A699-1]
DR RefSeq; NP_954670.2; NM_199200.2. [A2A699-1]
DR AlphaFoldDB; A2A699; -.
DR BioGRID; 229868; 3.
DR IntAct; A2A699; 4.
DR MINT; A2A699; -.
DR STRING; 10090.ENSMUSP00000038486; -.
DR GlyConnect; 2627; 4 N-Linked glycans (2 sites).
DR GlyGen; A2A699; 4 sites, 4 N-linked glycans (2 sites).
DR iPTMnet; A2A699; -.
DR PhosphoSitePlus; A2A699; -.
DR SwissPalm; A2A699; -.
DR EPD; A2A699; -.
DR jPOST; A2A699; -.
DR MaxQB; A2A699; -.
DR PaxDb; A2A699; -.
DR PeptideAtlas; A2A699; -.
DR PRIDE; A2A699; -.
DR ProteomicsDB; 271826; -. [A2A699-1]
DR ProteomicsDB; 271827; -. [A2A699-2]
DR Antibodypedia; 8250; 28 antibodies from 13 providers.
DR DNASU; 217219; -.
DR Ensembl; ENSMUST00000049057; ENSMUSP00000038486; ENSMUSG00000034685. [A2A699-1]
DR GeneID; 217219; -.
DR KEGG; mmu:217219; -.
DR UCSC; uc007lrw.2; mouse. [A2A699-1]
DR CTD; 284069; -.
DR MGI; MGI:2448496; Fam171a2.
DR VEuPathDB; HostDB:ENSMUSG00000034685; -.
DR eggNOG; ENOG502QTDH; Eukaryota.
DR GeneTree; ENSGT00950000183184; -.
DR HOGENOM; CLU_019729_0_0_1; -.
DR InParanoid; A2A699; -.
DR OMA; WVIVTAS; -.
DR OrthoDB; 615320at2759; -.
DR PhylomeDB; A2A699; -.
DR TreeFam; TF331338; -.
DR BioGRID-ORCS; 217219; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Fam171a2; mouse.
DR PRO; PR:A2A699; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; A2A699; protein.
DR Bgee; ENSMUSG00000034685; Expressed in cortical plate and 139 other tissues.
DR Genevisible; A2A699; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018890; FAM171.
DR PANTHER; PTHR31626; PTHR31626; 1.
DR Pfam; PF10577; UPF0560; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..822
FT /note="Protein FAM171A2"
FT /id="PRO_0000328772"
FT TOPO_DOM 30..315
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..822
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 378..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..708
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..822
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 369
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 371
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 785
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 221
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..184
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032783"
SQ SEQUENCE 822 AA; 87487 MW; AA4A1CA28B3E4516 CRC64;
MPPPSGPGVL ARLLPLLGLL LGGASRAPGK SPPEPPSPQE ILIKVQVYVS GELVPLARAS
VDVFGNRTLL AAGTTDSEGV ATLPLSYRLG TWVLVTAARP GFLTNSVPWR VDKLPLYASV
SLYLLPERPA TLILYEDLVH ILLGSPGARS QPWVQFQRRA ARLPVSSTYS QLWASLTPAS
TQQEMRAFPA FLGTEASSSG NGSWLELIPL AAVSVHLLTG NGTEVPLSGP IHLSLPVPSE
PRALAVGTSI PAWRFDPKSG LWVRNGTGVI RKEGRQLYWT FVSPQLGYWV AAMASPTSGL
VTITSGIQDI GTYHTIFLLT ILAALALLVL ILLCLLIYYC RRRCLKPRQQ HRKLQLSGPS
DNKRDQATSM SQLHLICGGP LEPTSSGDPE APPPGSLHSA FSSSRDLASS RDDFFRAKPR
SASRPAAEPP GARTVEGAGL KSARSVEGPG GLEPSLDEYR RGPAGAAAFL HEPPSPPPSF
DHYLGHKGAA ESKTPDFLLS QSVDQLARPP SLSQPGQLIF CGSIDHLKDN VYRNVMPTLV
IPAHYVRLGG EAGAAGVGDE ATPPEGSAAG PARPFPQPDP QRPLMQGHAG AGGDSGGGEG
WGGGRSAPVS GSVTIPVLFN ESTMAQLNGE LQALTEKKLL ELGVKPHPRA WFVSLDGRSN
SQVRHSYIDL QAGSGGRSTD ASLDSGVDVH EARPARRRLP REERERAQLP APPPPAPPRL
ALSEDTEPSS SESRTGLCSP EDNSLTPLLD EVVAPEGRAA TVPRGRGRSR GDSSRSSASE
LRRDSLTSPE DELGAEVGDE AGDKKSPWQR REERPLMVFN VK
