F171B_MOUSE
ID F171B_MOUSE Reviewed; 825 AA.
AC Q14CH0; Q8C756; Q8CAF3; Q8CBZ4; Q8CFT5;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Protein FAM171B;
DE Flags: Precursor;
GN Name=Fam171b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Diencephalon, Hypothalamus, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-792, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14CH0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14CH0-2; Sequence=VSP_025343;
CC -!- SIMILARITY: Belongs to the FAM171 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC28648.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK034250; BAC28648.1; ALT_INIT; mRNA.
DR EMBL; AK038899; BAC30163.1; -; mRNA.
DR EMBL; AK052508; BAC35021.1; -; mRNA.
DR EMBL; AL772256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL772301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC038086; AAH38086.1; -; mRNA.
DR EMBL; BC113787; AAI13788.1; -; mRNA.
DR CCDS; CCDS16182.1; -. [Q14CH0-2]
DR RefSeq; NP_780723.1; NM_175514.2. [Q14CH0-2]
DR AlphaFoldDB; Q14CH0; -.
DR IntAct; Q14CH0; 1.
DR MINT; Q14CH0; -.
DR STRING; 10090.ENSMUSP00000062702; -.
DR GlyConnect; 2628; 1 N-Linked glycan (1 site).
DR GlyGen; Q14CH0; 3 sites, 1 N-linked glycan (1 site).
DR iPTMnet; Q14CH0; -.
DR PhosphoSitePlus; Q14CH0; -.
DR MaxQB; Q14CH0; -.
DR PaxDb; Q14CH0; -.
DR PeptideAtlas; Q14CH0; -.
DR PRIDE; Q14CH0; -.
DR ProteomicsDB; 267680; -. [Q14CH0-1]
DR ProteomicsDB; 267681; -. [Q14CH0-2]
DR Antibodypedia; 2501; 53 antibodies from 11 providers.
DR DNASU; 241520; -.
DR Ensembl; ENSMUST00000051454; ENSMUSP00000062702; ENSMUSG00000048388. [Q14CH0-2]
DR GeneID; 241520; -.
DR KEGG; mmu:241520; -.
DR UCSC; uc008kie.1; mouse. [Q14CH0-2]
DR CTD; 165215; -.
DR MGI; MGI:2444579; Fam171b.
DR VEuPathDB; HostDB:ENSMUSG00000048388; -.
DR eggNOG; ENOG502QRHY; Eukaryota.
DR GeneTree; ENSGT00950000183184; -.
DR HOGENOM; CLU_019729_0_1_1; -.
DR InParanoid; Q14CH0; -.
DR OMA; WIAAPHP; -.
DR OrthoDB; 406002at2759; -.
DR PhylomeDB; Q14CH0; -.
DR TreeFam; TF331338; -.
DR BioGRID-ORCS; 241520; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Fam171b; mouse.
DR PRO; PR:Q14CH0; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q14CH0; protein.
DR Bgee; ENSMUSG00000048388; Expressed in rostral migratory stream and 200 other tissues.
DR Genevisible; Q14CH0; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018890; FAM171.
DR PANTHER; PTHR31626; PTHR31626; 1.
DR Pfam; PF10577; UPF0560; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..825
FT /note="Protein FAM171B"
FT /id="PRO_0000287149"
FT TOPO_DOM 33..353
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 375..825
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 52..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 792
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 214
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 43..46
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025343"
FT CONFLICT 66
FT /note="G -> E (in Ref. 3; AAI13788)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 825 AA; 92045 MW; 29F78257E8A8BCD6 CRC64;
MARLCRRVPC ALLLGLAAVL LKARLVPAAA RAELSRSDLS LIQQQQQQQQ QQQLQEQKQR
EEAEEGRPEV PGASSTLVAP VSVFMLKVQV NDIVSRQYLS QAVVEVFVNY SKTNSTVTRS
NGAVLIKVPY QLGLSLTIVA YKDGYVLTSL PWKTGRMPIY SSVTLSLFPQ SQANIWLFED
TVLITGKLAD AKSQPSVQFS KAFIKLPDNH HISNVTGYLT VLHQFLKVDS FLPATGVTYK
SGLENVELTP HAAICVKIYS GGKELKVDGS IHVSLPLLHT SNIKIGDRIP AWTFDMNAGV
WVHHGWGTVK EHNSHLIWTY DAPHLGYWIA APSPATLDFG INDDFQDITA YHTVFLTAIL
GGTIVIIIGF FAILLCYCRG KCATPQKRER NITKLEILKR DQTTSTTHIN HISSVKTALK
AEDKPQLFNA KTSSYSPQRK ETTKTEAEER ISMVKTRDNF KIYNEDVSFL SVNHNYSRNP
TQSLEPSMGS KQPKHINNNL SPSLGDAQEE KRYLTGTEEV YGRSHIPEQL MHIYSQPIAI
LQTSDLFSMP EQLHAAKSAT LPRKGQLVYG QLMEPVNREN FTQTLPKMPM HSHVQAPDAR
EEDIVLEGQQ SLPSQTSDWS RYSNSLLESV SVPGTLNEAV VMTPFSSELQ GISEQTLLEL
SKGKPPHPRA WFVSLDGKPV AQVRHSFIDL KKGKRTQSND TSLDSGVDMN EHQSSRKLER
EKTFIKSMHQ PKILYLEDLD LSSSESGTTV CSPEDPALRH ILEGGSGVII EHPGEESPGR
KSTVEDFEAN TSPTKKRGRP PPLAKRDSKT NIWKKREERP LIPLN
