ID   F172A_CHICK             Reviewed;         416 AA.
AC   Q5ZK44;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Cotranscriptional regulator FAM172A homolog {ECO:0000250|UniProtKB:Q3TNH5};
DE   AltName: Full=Protein FAM172A;
DE   Flags: Precursor;
GN   Name=FAM172A; ORFNames=RCJMB04_13e16;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May play role in the regulation of alternative splicing. May
CC       have hydrolase activity. {ECO:0000250|UniProtKB:Q3TNH5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3TNH5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q3TNH5}.
CC   -!- SIMILARITY: Belongs to the FAM172 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ720240; CAG31899.1; -; mRNA.
DR   RefSeq; NP_001006574.1; NM_001006574.1.
DR   AlphaFoldDB; Q5ZK44; -.
DR   SMR; Q5ZK44; -.
DR   STRING; 9031.ENSGALP00000036880; -.
DR   ESTHER; chick-f172a; Arb2_FAM172A.
DR   PaxDb; Q5ZK44; -.
DR   Ensembl; ENSGALT00000023631; ENSGALP00000023585; ENSGALG00000014661.
DR   Ensembl; ENSGALT00000087501; ENSGALP00000064299; ENSGALG00000014661.
DR   GeneID; 427109; -.
DR   KEGG; gga:427109; -.
DR   CTD; 83989; -.
DR   VEuPathDB; HostDB:geneid_427109; -.
DR   eggNOG; KOG3967; Eukaryota.
DR   GeneTree; ENSGT00530000063907; -.
DR   HOGENOM; CLU_048484_2_1_1; -.
DR   InParanoid; Q5ZK44; -.
DR   OMA; CNWVSST; -.
DR   OrthoDB; 1036194at2759; -.
DR   PhylomeDB; Q5ZK44; -.
DR   PRO; PR:Q5ZK44; -.
DR   Proteomes; UP000000539; Chromosome Z.
DR   Bgee; ENSGALG00000014661; Expressed in colon and 13 other tissues.
DR   ExpressionAtlas; Q5ZK44; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0031048; P:heterochromatin assembly by small RNA; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0014032; P:neural crest cell development; IEA:Ensembl.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Ensembl.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR039929; FAM172A.
DR   PANTHER; PTHR21357:SF3; PTHR21357:SF3; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Glycoprotein; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..416
FT                   /note="Cotranscriptional regulator FAM172A homolog"
FT                   /id="PRO_0000320933"
FT   REGION          211..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..248
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        293
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250|UniProtKB:Q3TNH5"
FT   CARBOHYD        397
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   416 AA;  48354 MW;  06B94BF310ED4208 CRC64;
     MHFYFNVLNL LTVWVMMAQL QQGVPDEKEK TTALKDLLSR IDLDELMKKD EPPLEFPDTL
     EGFEYSFNEK GQLRHAKTGE PFVFNYREDL HRWNQKRYEA LGEIITKHVY GLLEKECHLK
     KVTLPVDATE NEPKSFIFMS EDALTNPDKL LVLIHGNGVV RAGQWARRLI INEDLDSGTQ
     IPYIKKATEE GYGVIVLNPN ENYIEVEKTK AQVQLSSDSS DEPAEKRERK DKIQKETKKR
     RDFYEKYRNP QKEKETMQMY IRDNGSPEEH AIYVWDHFIS QSAAENVFFV AHSYGGLAFV
     ELMIQRETEV KNKVTAVALT DSVHNVWHQE AGKTIREWMR ENCCNWVSSS EPLDTSVESM
     LPDCPRVSAG TERHELTSWK SFPSIFKFFS EAMEAKNSSV KPAPTRRSNR IKYEEL