ID   F172A_DANRE             Reviewed;         415 AA.
AC   Q7T297;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Cotranscriptional regulator FAM172A homolog {ECO:0000250|UniProtKB:Q3TNH5};
DE   AltName: Full=Protein FAM172A;
DE   Flags: Precursor;
GN   Name=fam172a; ORFNames=zgc:64188;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play role in the regulation of alternative splicing. May
CC       have hydrolase activity. {ECO:0000250|UniProtKB:Q3TNH5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3TNH5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q3TNH5}.
CC   -!- SIMILARITY: Belongs to the FAM172 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH54635.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC054635; AAH54635.1; ALT_INIT; mRNA.
DR   RefSeq; NP_956712.1; NM_200418.1.
DR   AlphaFoldDB; Q7T297; -.
DR   SMR; Q7T297; -.
DR   STRING; 7955.ENSDARP00000069087; -.
DR   ESTHER; danre-f172a; Arb2_FAM172A.
DR   PaxDb; Q7T297; -.
DR   GeneID; 393390; -.
DR   KEGG; dre:393390; -.
DR   CTD; 83989; -.
DR   ZFIN; ZDB-GENE-040426-1396; fam172a.
DR   eggNOG; KOG3967; Eukaryota.
DR   InParanoid; Q7T297; -.
DR   PhylomeDB; Q7T297; -.
DR   PRO; PR:Q7T297; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0031048; P:heterochromatin assembly by small RNA; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR039929; FAM172A.
DR   PANTHER; PTHR21357:SF3; PTHR21357:SF3; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..415
FT                   /note="Cotranscriptional regulator FAM172A homolog"
FT                   /id="PRO_0000320934"
FT   REGION          204..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        205..242
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        290
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250|UniProtKB:Q3TNH5"
SQ   SEQUENCE   415 AA;  48208 MW;  C6571793EC0721CA CRC64;
     MFFRASFFLF GLVWITMAQL LAQDEKEKTT ALKDLLSRID LDELMKKDEP PLDFPETLDG
     FEYAFNEQGQ LRHTKTGEPF VFNYKEDLHR WNQKRYEALG EIITKYVYER LEKDCNLKKE
     ILPVDATEDE PKSFIYVSED ALSNPDKIMV LIQGSGVVRA GQWARRLIIN EDLNSGTQIP
     FINRAKEEGY GVIVLNPNEN SLEVEKVSDP AKKASPDASD EPAEKRERKE ERENKKKKDF
     YEKYRNPQKE REMEHIPIRE NGSPEEHTLY AWDYFISKSL AKNIFIVAHS YGGLSFVNLM
     INREAEVKSR VRAVAMTDSV HNVWHQEASK SIQDWLREHC CNWVSSPEPL DTLVDPMLND
     CPRVSAGTEK HELTSWKSFQ SIFKFFSNAL KDHEDDSSSS PVTTRSSHRI KHEDF