ID   F172A_DICDI             Reviewed;         385 AA.
AC   Q557B6; Q86JR6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=FAM172 family protein homolog;
GN   ORFNames=DDB_G0273237;
GN   and
GN   ORFNames=DDB_G0273673;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the FAM172 family. {ECO:0000305}.
CC   -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC       AX4. These strains contain a duplication of a segment of 750 kb of
CC       chromosome 2 compared to the corresponding sequence in strain AX2.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000011; EAL70527.1; -; Genomic_DNA.
DR   EMBL; AAFI02000009; EAL70836.1; -; Genomic_DNA.
DR   RefSeq; XP_644453.1; XM_639361.1.
DR   RefSeq; XP_644797.1; XM_639705.1.
DR   AlphaFoldDB; Q557B6; -.
DR   STRING; 44689.DDB0234078; -.
DR   PaxDb; Q557B6; -.
DR   EnsemblProtists; EAL70527; EAL70527; DDB_G0273673.
DR   EnsemblProtists; EAL70836; EAL70836; DDB_G0273237.
DR   GeneID; 8618899; -.
DR   GeneID; 8619078; -.
DR   KEGG; ddi:DDB_G0273237; -.
DR   KEGG; ddi:DDB_G0273673; -.
DR   dictyBase; DDB_G0273237; -.
DR   dictyBase; DDB_G0273673; -.
DR   eggNOG; KOG3967; Eukaryota.
DR   HOGENOM; CLU_048484_0_0_1; -.
DR   InParanoid; Q557B6; -.
DR   OMA; CNWVSST; -.
DR   PhylomeDB; Q557B6; -.
DR   PRO; PR:Q557B6; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0031048; P:heterochromatin assembly by small RNA; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..385
FT                   /note="FAM172 family protein homolog"
FT                   /id="PRO_0000336086"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          220..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..44
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   385 AA;  43925 MW;  7876C18B4E5C54A7 CRC64;
     MSDIEKEENK DSSPPTTPPT GGPTKNNDID DDEKENKIER SLTENLNKRF YNNNNNNSNN
     SNGEEIEDID YKNFKTIKEF GYYYNDKGEL RSIEGEEKFK FINQQQYDRL GDIIVKTIQN
     KMKSEPINLE EHWIPKGETN QCNIFTSKDF FENPTKLMVF INGSGAVKSG QWARSLCIND
     TLNTGSILPY LNDAISNDFS IIVLNPNYNV FEERIIEEGE EQKEKAKEEE EKKDDNGKLL
     KKKRVDNSIK GSENSNNHIL TVYDEFIKKS PAKEIVIVAH SFGGVNTTYL LDNRGEEIAD
     RLKSIAFTDS VHSLSPKSSS FTKSFFADEN KTKNWVKSDK KLNTDLGFSK LQGCNIASSG
     HRVHEFTSSA CRVPLFQFIL NSLKK