F172A_DROME
ID F172A_DROME Reviewed; 325 AA.
AC Q95RN0; Q86BS1; Q9VGA6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=FAM172 family protein homolog CG10038;
GN ORFNames=CG10038;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=Q95RN0-1; Sequence=Displayed;
CC Name=B;
CC IsoId=Q95RN0-2; Sequence=VSP_031753;
CC -!- SIMILARITY: Belongs to the FAM172 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF54777.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF54778.2; -; Genomic_DNA.
DR EMBL; AY061267; AAL28815.1; -; mRNA.
DR RefSeq; NP_650176.3; NM_141919.4. [Q95RN0-1]
DR RefSeq; NP_731685.1; NM_169460.3. [Q95RN0-2]
DR AlphaFoldDB; Q95RN0; -.
DR STRING; 7227.FBpp0082085; -.
DR PaxDb; Q95RN0; -.
DR PRIDE; Q95RN0; -.
DR DNASU; 41495; -.
DR EnsemblMetazoa; FBtr0082614; FBpp0082084; FBgn0038013. [Q95RN0-2]
DR EnsemblMetazoa; FBtr0082615; FBpp0082085; FBgn0038013. [Q95RN0-1]
DR GeneID; 41495; -.
DR KEGG; dme:Dmel_CG10038; -.
DR UCSC; CG10038-RA; d. melanogaster. [Q95RN0-1]
DR FlyBase; FBgn0038013; CG10038.
DR VEuPathDB; VectorBase:FBgn0038013; -.
DR eggNOG; KOG3967; Eukaryota.
DR GeneTree; ENSGT00530000063907; -.
DR InParanoid; Q95RN0; -.
DR PhylomeDB; Q95RN0; -.
DR BioGRID-ORCS; 41495; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41495; -.
DR PRO; PR:Q95RN0; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038013; Expressed in eye disc (Drosophila) and 22 other tissues.
DR Genevisible; Q95RN0; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0017171; F:serine hydrolase activity; HDA:FlyBase.
DR GO; GO:0031048; P:heterochromatin assembly by small RNA; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..325
FT /note="FAM172 family protein homolog CG10038"
FT /id="PRO_0000320937"
FT VAR_SEQ 1..16
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_031753"
SQ SEQUENCE 325 AA; 36561 MW; F2575EE9617AD0CA CRC64;
MWSRLIQIFR PLRSFRMSHS PPPASNCEEA LIQLKNFGYA FDGEGVLRKV DPATGEPGKE
LFSYNVSDDA AENEKHYQKL ANQIPEIVYA LLEKNGLSRT YIPFDQPPER SSFVFSQPAK
LSQSKKLLVL IHGSGYVKAG QWARSLIINN SLDHGTQLPY VRQAQKLGYD LLITNANDCT
RFYNGKENPI KGVNTSVEHV KYVWKNIVLP AKPESVAIVA HSYGGSLTLD LVERFPDFFK
ESVFAIAFTD AAMGSPQAKN KEYLCDVACD WVASNTPLDT PVSQSKSSIR RISAGHTKHE
WTSYSAIDSV FKFIEEKYEQ RANKK
