ID   F172A_XENTR             Reviewed;         422 AA.
AC   Q6DIP8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Cotranscriptional regulator FAM172A homolog {ECO:0000250|UniProtKB:Q3TNH5};
DE   AltName: Full=Protein FAM172A;
DE   Flags: Precursor;
GN   Name=fam172a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play role in the regulation of alternative splicing. May
CC       have hydrolase activity. {ECO:0000250|UniProtKB:Q3TNH5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3TNH5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q3TNH5}.
CC   -!- SIMILARITY: Belongs to the FAM172 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH75487.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC075487; AAH75487.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001004971.1; NM_001004971.1.
DR   RefSeq; XP_012815235.1; XM_012959781.2.
DR   RefSeq; XP_012815238.1; XM_012959784.2.
DR   RefSeq; XP_017947671.1; XM_018092182.1.
DR   AlphaFoldDB; Q6DIP8; -.
DR   SMR; Q6DIP8; -.
DR   STRING; 8364.ENSXETP00000025347; -.
DR   ESTHER; xentr-f172a; Arb2_FAM172A.
DR   PaxDb; Q6DIP8; -.
DR   DNASU; 448398; -.
DR   GeneID; 448398; -.
DR   KEGG; xtr:448398; -.
DR   CTD; 83989; -.
DR   Xenbase; XB-GENE-942392; fam172a.
DR   eggNOG; KOG3967; Eukaryota.
DR   InParanoid; Q6DIP8; -.
DR   OrthoDB; 1036194at2759; -.
DR   PhylomeDB; Q6DIP8; -.
DR   TreeFam; TF315960; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000011592; Expressed in liver and 12 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0031048; P:heterochromatin assembly by small RNA; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR019154; Arb2_domain.
DR   InterPro; IPR039929; FAM172A.
DR   PANTHER; PTHR21357:SF3; PTHR21357:SF3; 1.
DR   Pfam; PF09757; Arb2; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..422
FT                   /note="Cotranscriptional regulator FAM172A homolog"
FT                   /id="PRO_0000320935"
FT   REGION          213..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          403..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..253
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        299
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250|UniProtKB:Q3TNH5"
SQ   SEQUENCE   422 AA;  48981 MW;  7FD24CABB3AB0950 CRC64;
     MKLEIKCFII CKVLPLVWLN MAQIQQVGAP EEKEKTTALK DLLSRIDLDE LMKKDEPPLE
     FPDTLEGFNY AFNELGQLRH IQTGDPFVFN YREDLHRWNQ KRYEALGEII TKHVYELLEK
     DCELEKVYLP VDATDSEPRS FIFMSKDAMT NPDKMLVLIH GSGVVRAGQW ARRLIINEDL
     NSGSQIPYIK RAMKEGYAVI VLNPNENYIE VEKSKVPADQ PSPDSSDEPA EKRERRERNP
     KETKKRRDFY EKYRNPQKEK ETLQVYIRDN GSPEEHALYV WDNFISKAAA ENILFVAHSY
     GGLTFVELMI QREADVKNKV AAVALTDSVH NVWHQDASKT LREWMRENCC NWVSSSEPLD
     TSVESTLPDC PRVSAGTERH ELTSWKSFHS IFKFFDDALQ AKNTKTKPTP TRRSNRIKHE
     DL