F174A_HUMAN
ID F174A_HUMAN Reviewed; 190 AA.
AC Q8TBP5; A8K0H4;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Membrane protein FAM174A;
DE AltName: Full=Hepatitis C virus NS5A-transactivated protein 6;
DE Short=HCV NS5A-transactivated protein 6;
DE AltName: Full=Transmembrane protein 157;
DE Flags: Precursor;
GN Name=FAM174A; Synonyms=NS5ATP6, TMEM157; ORFNames=UNQ1912/PRO4371;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Liu Y., Cheng J., Wang G., Wang J., Zhang L., Chen J., Li L.;
RT "Cloning and identification of human gene 6 transactivated by hepatitis C
RT virus NS5A protein.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Adrenal cortex;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8TBP5; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-18636064, EBI-12109402;
CC Q8TBP5; O15155: BET1; NbExp=3; IntAct=EBI-18636064, EBI-749204;
CC Q8TBP5; Q12981: BNIP1; NbExp=3; IntAct=EBI-18636064, EBI-4402847;
CC Q8TBP5; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-18636064, EBI-12003442;
CC Q8TBP5; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-18636064, EBI-9083477;
CC Q8TBP5; Q96FZ5: CMTM7; NbExp=3; IntAct=EBI-18636064, EBI-2807956;
CC Q8TBP5; Q9H1M4: DEFB127; NbExp=3; IntAct=EBI-18636064, EBI-10305240;
CC Q8TBP5; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-18636064, EBI-711490;
CC Q8TBP5; Q14318: FKBP8; NbExp=3; IntAct=EBI-18636064, EBI-724839;
CC Q8TBP5; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-18636064, EBI-11991950;
CC Q8TBP5; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-18636064, EBI-6166686;
CC Q8TBP5; O14653: GOSR2; NbExp=3; IntAct=EBI-18636064, EBI-4401517;
CC Q8TBP5; P09601: HMOX1; NbExp=3; IntAct=EBI-18636064, EBI-2806151;
CC Q8TBP5; Q8N912: NRAC; NbExp=3; IntAct=EBI-18636064, EBI-12051377;
CC Q8TBP5; Q9Y342: PLLP; NbExp=3; IntAct=EBI-18636064, EBI-3919291;
CC Q8TBP5; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-18636064, EBI-11721828;
CC Q8TBP5; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-18636064, EBI-10244780;
CC Q8TBP5; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-18636064, EBI-8652744;
CC Q8TBP5; O75396: SEC22B; NbExp=3; IntAct=EBI-18636064, EBI-1058865;
CC Q8TBP5; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-18636064, EBI-10329948;
CC Q8TBP5; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-18636064, EBI-8644112;
CC Q8TBP5; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-18636064, EBI-8640191;
CC Q8TBP5; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-18636064, EBI-12188413;
CC Q8TBP5; O15400: STX7; NbExp=3; IntAct=EBI-18636064, EBI-3221827;
CC Q8TBP5; Q9UNK0: STX8; NbExp=3; IntAct=EBI-18636064, EBI-727240;
CC Q8TBP5; P17152: TMEM11; NbExp=3; IntAct=EBI-18636064, EBI-723946;
CC Q8TBP5; Q969S6: TMEM203; NbExp=3; IntAct=EBI-18636064, EBI-12274070;
CC Q8TBP5; Q9H0R3: TMEM222; NbExp=3; IntAct=EBI-18636064, EBI-347385;
CC Q8TBP5; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-18636064, EBI-11528917;
CC Q8TBP5; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-18636064, EBI-12887458;
CC Q8TBP5; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-18636064, EBI-12038591;
CC Q8TBP5; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-18636064, EBI-6656213;
CC Q8TBP5; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-18636064, EBI-16746122;
CC Q8TBP5; Q15836: VAMP3; NbExp=3; IntAct=EBI-18636064, EBI-722343;
CC Q8TBP5; O95292: VAPB; NbExp=3; IntAct=EBI-18636064, EBI-1188298;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM174 family. {ECO:0000305}.
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DR EMBL; AF529367; AAQ09601.1; -; mRNA.
DR EMBL; AY359108; AAQ89466.1; -; mRNA.
DR EMBL; AK289539; BAF82228.1; -; mRNA.
DR EMBL; AC021086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471086; EAW49106.1; -; Genomic_DNA.
DR EMBL; BC027332; AAH27332.1; -; mRNA.
DR CCDS; CCDS4090.1; -.
DR RefSeq; NP_940909.1; NM_198507.2.
DR AlphaFoldDB; Q8TBP5; -.
DR SMR; Q8TBP5; -.
DR BioGRID; 131364; 255.
DR IntAct; Q8TBP5; 83.
DR STRING; 9606.ENSP00000307954; -.
DR GlyConnect; 2926; 2 O-Linked glycans (2 sites).
DR GlyGen; Q8TBP5; 3 sites, 3 O-linked glycans (1 site).
DR iPTMnet; Q8TBP5; -.
DR PhosphoSitePlus; Q8TBP5; -.
DR BioMuta; FAM174A; -.
DR DMDM; 74730492; -.
DR EPD; Q8TBP5; -.
DR jPOST; Q8TBP5; -.
DR MassIVE; Q8TBP5; -.
DR MaxQB; Q8TBP5; -.
DR PaxDb; Q8TBP5; -.
DR PeptideAtlas; Q8TBP5; -.
DR PRIDE; Q8TBP5; -.
DR ProteomicsDB; 74036; -.
DR Antibodypedia; 13308; 55 antibodies from 14 providers.
DR DNASU; 345757; -.
DR Ensembl; ENST00000312637.5; ENSP00000307954.2; ENSG00000174132.9.
DR GeneID; 345757; -.
DR KEGG; hsa:345757; -.
DR MANE-Select; ENST00000312637.5; ENSP00000307954.2; NM_198507.3; NP_940909.1.
DR UCSC; uc003knj.2; human.
DR CTD; 345757; -.
DR DisGeNET; 345757; -.
DR GeneCards; FAM174A; -.
DR HGNC; HGNC:24943; FAM174A.
DR HPA; ENSG00000174132; Low tissue specificity.
DR neXtProt; NX_Q8TBP5; -.
DR OpenTargets; ENSG00000174132; -.
DR PharmGKB; PA162387296; -.
DR VEuPathDB; HostDB:ENSG00000174132; -.
DR eggNOG; ENOG502S4HB; Eukaryota.
DR GeneTree; ENSGT00730000111385; -.
DR HOGENOM; CLU_126641_0_0_1; -.
DR InParanoid; Q8TBP5; -.
DR OMA; HCSCCLS; -.
DR OrthoDB; 1515948at2759; -.
DR PhylomeDB; Q8TBP5; -.
DR TreeFam; TF105425; -.
DR PathwayCommons; Q8TBP5; -.
DR SignaLink; Q8TBP5; -.
DR BioGRID-ORCS; 345757; 10 hits in 1073 CRISPR screens.
DR ChiTaRS; FAM174A; human.
DR GenomeRNAi; 345757; -.
DR Pharos; Q8TBP5; Tdark.
DR PRO; PR:Q8TBP5; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8TBP5; protein.
DR Bgee; ENSG00000174132; Expressed in bronchial epithelial cell and 183 other tissues.
DR Genevisible; Q8TBP5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR009565; DUF1180.
DR PANTHER; PTHR28607; PTHR28607; 1.
DR Pfam; PF06679; DUF1180; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..190
FT /note="Membrane protein FAM174A"
FT /id="PRO_0000263650"
FT TOPO_DOM 30..123
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..190
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 42..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..64
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 190 AA; 19954 MW; 8E2B9CB2B8FB72AD CRC64;
MKASQCCCCL SHLLASVLLL LLLPELSGPL AVLLQAAEAA PGLGPPDPRP RTLPPLPPGP
TPAQQPGRGL AEAAGPRGSE GGNGSNPVAG LETDDHGGKA GEGSVGGGLA VSPNPGDKPM
TQRALTVLMV VSGAVLVYFV VRTVRMRRRN RKTRRYGVLD TNIENMELTP LEQDDEDDDN
TLFDANHPRR
