F174A_MOUSE
ID F174A_MOUSE Reviewed; 190 AA.
AC Q9D3L0; Q3UF92; Q8CC46; Q8VDR1; Q9D238; Q9D6W5; Q9D6Z3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Membrane protein FAM174A;
DE AltName: Full=Transmembrane protein 157;
DE Flags: Precursor;
GN Name=Fam174a; Synonyms=Tmem157;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Diencephalon, Head, Sympathetic ganglion, Tongue, and
RC Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM174 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB26509.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB26567.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAE28669.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK009797; BAB26509.1; ALT_FRAME; mRNA.
DR EMBL; AK009892; BAB26567.1; ALT_FRAME; mRNA.
DR EMBL; AK017318; BAB30690.1; -; mRNA.
DR EMBL; AK020633; BAB32159.1; -; mRNA.
DR EMBL; AK033948; BAC28523.1; -; mRNA.
DR EMBL; AK148807; BAE28669.1; ALT_FRAME; mRNA.
DR EMBL; BC021428; AAH21428.1; -; mRNA.
DR CCDS; CCDS35674.1; -.
DR RefSeq; NP_080597.2; NM_026321.4.
DR AlphaFoldDB; Q9D3L0; -.
DR SMR; Q9D3L0; -.
DR STRING; 10090.ENSMUSP00000057670; -.
DR GlyGen; Q9D3L0; 1 site.
DR PhosphoSitePlus; Q9D3L0; -.
DR PaxDb; Q9D3L0; -.
DR PRIDE; Q9D3L0; -.
DR ProteomicsDB; 275510; -.
DR Antibodypedia; 13308; 55 antibodies from 14 providers.
DR DNASU; 67698; -.
DR Ensembl; ENSMUST00000059975; ENSMUSP00000057670; ENSMUSG00000051185.
DR Ensembl; ENSMUST00000186780; ENSMUSP00000139943; ENSMUSG00000051185.
DR GeneID; 67698; -.
DR KEGG; mmu:67698; -.
DR UCSC; uc007cex.2; mouse.
DR CTD; 345757; -.
DR MGI; MGI:1914948; Fam174a.
DR VEuPathDB; HostDB:ENSMUSG00000051185; -.
DR eggNOG; ENOG502S4HB; Eukaryota.
DR GeneTree; ENSGT00730000111385; -.
DR HOGENOM; CLU_126641_0_0_1; -.
DR InParanoid; Q9D3L0; -.
DR OMA; HCSCCLS; -.
DR OrthoDB; 1507319at2759; -.
DR PhylomeDB; Q9D3L0; -.
DR TreeFam; TF105425; -.
DR BioGRID-ORCS; 67698; 2 hits in 74 CRISPR screens.
DR PRO; PR:Q9D3L0; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9D3L0; protein.
DR Bgee; ENSMUSG00000051185; Expressed in median eminence of neurohypophysis and 240 other tissues.
DR Genevisible; Q9D3L0; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR009565; DUF1180.
DR PANTHER; PTHR28607; PTHR28607; 1.
DR Pfam; PF06679; DUF1180; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..190
FT /note="Membrane protein FAM174A"
FT /id="PRO_0000263651"
FT TOPO_DOM 32..123
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..190
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 37..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 33
FT /note="P -> R (in Ref. 2; AAH21428)"
FT /evidence="ECO:0000305"
FT CONFLICT 84
FT /note="D -> G (in Ref. 2; AAH21428)"
FT /evidence="ECO:0000305"
FT CONFLICT 131
FT /note="V -> G (in Ref. 1; BAB26509)"
FT /evidence="ECO:0000305"
FT CONFLICT 134
FT /note="A -> P (in Ref. 1; BAB26509)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="V -> G (in Ref. 1; BAB26509)"
FT /evidence="ECO:0000305"
FT CONFLICT 144
FT /note="V -> I (in Ref. 2; AAH21428)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="K -> R (in Ref. 1; BAB32159)"
FT /evidence="ECO:0000305"
FT CONFLICT 166
FT /note="M -> K (in Ref. 1; BAB30690)"
FT /evidence="ECO:0000305"
FT CONFLICT 176
FT /note="E -> K (in Ref. 1; BAB30690)"
FT /evidence="ECO:0000305"
FT CONFLICT 181
FT /note="T -> P (in Ref. 1; BAB26567)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="R -> K (in Ref. 1; BAB26567)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 190 AA; 19986 MW; D7EEB04A6E04D1F9 CRC64;
MPTPRGCSGP CHFLAPAFVL LLLPALSGSG AVPSMVVREV QESKSPKPGP HTLSPLPPGP
TAAQPRGQAQ SDAAGLPGAE SRNDSIPGAG SEADGLEGKA GEGSQGGSLA VSPSPGDKPM
TQRALTVLVV VSAAVLVYFV VRTVRMRRRN RKTRRYGVLD TNIENMELTP LEQDDEDDDN
TLFDANHPRR
