ID   F174B_DANRE             Reviewed;         133 AA.
AC   Q1LVN1; A7MD72;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Membrane protein FAM174B;
DE   Flags: Precursor;
GN   Name=Fam174b; ORFNames=si:ch211-196l7.3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for Golgi structural integrity.
CC       {ECO:0000250|UniProtKB:Q3ZCQ3}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q3ZCQ3};
CC       Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q3ZCQ3}.
CC   -!- SIMILARITY: Belongs to the FAM174 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAK04333.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; BX649578; CAK04333.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC152510; AAI52511.1; -; mRNA.
DR   RefSeq; NP_001096605.1; NM_001103135.1.
DR   AlphaFoldDB; Q1LVN1; -.
DR   SMR; Q1LVN1; -.
DR   STRING; 7955.ENSDARP00000123345; -.
DR   PaxDb; Q1LVN1; -.
DR   Ensembl; ENSDART00000099476; ENSDARP00000090250; ENSDARG00000068709.
DR   GeneID; 798908; -.
DR   KEGG; dre:798908; -.
DR   CTD; 400451; -.
DR   ZFIN; ZDB-GENE-050419-78; fam174b.
DR   eggNOG; ENOG502S4RE; Eukaryota.
DR   GeneTree; ENSGT00730000111392; -.
DR   InParanoid; Q1LVN1; -.
DR   OMA; TSKNDTH; -.
DR   PhylomeDB; Q1LVN1; -.
DR   TreeFam; TF105425; -.
DR   PRO; PR:Q1LVN1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 18.
DR   Bgee; ENSDARG00000068709; Expressed in heart and 20 other tissues.
DR   ExpressionAtlas; Q1LVN1; baseline.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0007030; P:Golgi organization; ISS:UniProtKB.
DR   InterPro; IPR009565; DUF1180.
DR   PANTHER; PTHR28607; PTHR28607; 1.
DR   Pfam; PF06679; DUF1180; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Golgi apparatus; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..133
FT                   /note="Membrane protein FAM174B"
FT                   /id="PRO_0000326116"
FT   TOPO_DOM        20..67
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..133
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          22..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        32
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   133 AA;  14877 MW;  0BB44DEE4B2A5026 CRC64;
     MWLYTFAVAL IVIAQEINGE PHTRPSSATP LNATLPPQEE GSAQNTTDAA VGSRLSTILR
     DLPTIKNISI FICVLTTLLI TCLVIKICRS ARKIRKTRKY DIITTPAERV EMAPLNEEND
     EEDDSTLFDV KYR