F174B_HUMAN
ID F174B_HUMAN Reviewed; 159 AA.
AC Q3ZCQ3; Q3ZCR9; Q8NBH7;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Membrane protein FAM174B;
DE Flags: Precursor;
GN Name=FAM174B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=29851555; DOI=10.1091/mbc.e17-11-0693;
RA Serebrenik Y.V., Hellerschmied D., Toure M., Lopez-Giraldez F.,
RA Brookner D., Crews C.M.;
RT "Targeted protein unfolding uncovers a Golgi-specific transcriptional
RT stress response.";
RL Mol. Biol. Cell 29:1284-1298(2018).
CC -!- FUNCTION: Essential for Golgi structural integrity.
CC {ECO:0000269|PubMed:29851555}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29851555};
CC Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus
CC {ECO:0000269|PubMed:29851555}.
CC -!- INDUCTION: Up-regulated by Golgi stress-inducing agent nigericin.
CC {ECO:0000269|PubMed:29851555}.
CC -!- SIMILARITY: Belongs to the FAM174 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH45729.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK075564; BAC11703.1; -; mRNA.
DR EMBL; AC091544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC045729; AAH45729.1; ALT_INIT; mRNA.
DR EMBL; BC060873; AAH60873.1; -; mRNA.
DR CCDS; CCDS45355.1; -.
DR RefSeq; NP_997329.2; NM_207446.2.
DR AlphaFoldDB; Q3ZCQ3; -.
DR STRING; 9606.ENSP00000329040; -.
DR GlyGen; Q3ZCQ3; 1 site.
DR iPTMnet; Q3ZCQ3; -.
DR PhosphoSitePlus; Q3ZCQ3; -.
DR BioMuta; FAM174B; -.
DR DMDM; 325511337; -.
DR EPD; Q3ZCQ3; -.
DR jPOST; Q3ZCQ3; -.
DR MassIVE; Q3ZCQ3; -.
DR PaxDb; Q3ZCQ3; -.
DR PeptideAtlas; Q3ZCQ3; -.
DR PRIDE; Q3ZCQ3; -.
DR ProteomicsDB; 61908; -.
DR Antibodypedia; 29037; 48 antibodies from 13 providers.
DR DNASU; 400451; -.
DR Ensembl; ENST00000327355.6; ENSP00000329040.5; ENSG00000185442.13.
DR GeneID; 400451; -.
DR KEGG; hsa:400451; -.
DR MANE-Select; ENST00000327355.6; ENSP00000329040.5; NM_207446.3; NP_997329.2.
DR UCSC; uc010boe.4; human.
DR CTD; 400451; -.
DR DisGeNET; 400451; -.
DR GeneCards; FAM174B; -.
DR HGNC; HGNC:34339; FAM174B.
DR HPA; ENSG00000185442; Tissue enhanced (pancreas).
DR neXtProt; NX_Q3ZCQ3; -.
DR OpenTargets; ENSG00000185442; -.
DR PharmGKB; PA162387297; -.
DR VEuPathDB; HostDB:ENSG00000185442; -.
DR eggNOG; ENOG502S4RE; Eukaryota.
DR GeneTree; ENSGT00730000111392; -.
DR HOGENOM; CLU_140744_1_0_1; -.
DR InParanoid; Q3ZCQ3; -.
DR OMA; PGNATGM; -.
DR OrthoDB; 1612806at2759; -.
DR PhylomeDB; Q3ZCQ3; -.
DR TreeFam; TF105425; -.
DR PathwayCommons; Q3ZCQ3; -.
DR BioGRID-ORCS; 400451; 10 hits in 1066 CRISPR screens.
DR ChiTaRS; FAM174B; human.
DR GenomeRNAi; 400451; -.
DR Pharos; Q3ZCQ3; Tdark.
DR PRO; PR:Q3ZCQ3; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q3ZCQ3; protein.
DR Bgee; ENSG00000185442; Expressed in body of pancreas and 162 other tissues.
DR ExpressionAtlas; Q3ZCQ3; baseline and differential.
DR Genevisible; Q3ZCQ3; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0007030; P:Golgi organization; IMP:UniProtKB.
DR InterPro; IPR009565; DUF1180.
DR PANTHER; PTHR28607; PTHR28607; 1.
DR Pfam; PF06679; DUF1180; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Golgi apparatus; Membrane; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..159
FT /note="Membrane protein FAM174B"
FT /id="PRO_0000326114"
FT TOPO_DOM 27..90
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 30..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 116
FT /note="S -> L (in dbSNP:rs34052034)"
FT /id="VAR_039989"
FT CONFLICT 23
FT /note="A -> T (in Ref. 1; BAC11703)"
FT /evidence="ECO:0000305"
FT CONFLICT 36
FT /note="W -> R (in Ref. 1; BAC11703 and 3; AAH60873)"
FT /evidence="ECO:0000305"
FT CONFLICT 67..68
FT /note="Missing (in Ref. 1; BAC11703 and 3; AAH60873)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 159 AA; 16967 MW; 9A10F95B563575B1 CRC64;
MRAVPLPAPL LPLLLLALLA APAARASRAE SVSAPWPEPE RESRPPPGPG PGNTTRFGSG
AAGGSGSSSS NSSGDALVTR ISILLRDLPT LKAAVIVAFA FTTLLIACLL LRVFRSGKRL
KKTRKYDIIT TPAERVEMAP LNEEDDEDED STVFDIKYR
