ID   F174B_MOUSE             Reviewed;         153 AA.
AC   Q8K064; Q2NLC2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Membrane protein FAM174B;
DE   Flags: Precursor;
GN   Name=Fam174b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon, and Olfactory epithelium;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Essential for Golgi structural integrity.
CC       {ECO:0000250|UniProtKB:Q3ZCQ3}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q3ZCQ3};
CC       Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q3ZCQ3}.
CC   -!- SIMILARITY: Belongs to the FAM174 family. {ECO:0000305}.
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DR   EMBL; AC136004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC034069; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC110691; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS52275.1; -.
DR   RefSeq; NP_001156004.1; NM_001162532.1.
DR   AlphaFoldDB; Q8K064; -.
DR   SMR; Q8K064; -.
DR   STRING; 10090.ENSMUSP00000103080; -.
DR   GlyGen; Q8K064; 1 site.
DR   iPTMnet; Q8K064; -.
DR   PhosphoSitePlus; Q8K064; -.
DR   MaxQB; Q8K064; -.
DR   PaxDb; Q8K064; -.
DR   PRIDE; Q8K064; -.
DR   ProteomicsDB; 271828; -.
DR   Antibodypedia; 29037; 48 antibodies from 13 providers.
DR   Ensembl; ENSMUST00000107456; ENSMUSP00000103080; ENSMUSG00000078670.
DR   GeneID; 100038347; -.
DR   KEGG; mmu:100038347; -.
DR   UCSC; uc009hrf.2; mouse.
DR   CTD; 400451; -.
DR   MGI; MGI:3698178; Fam174b.
DR   VEuPathDB; HostDB:ENSMUSG00000078670; -.
DR   eggNOG; ENOG502S4RE; Eukaryota.
DR   GeneTree; ENSGT00730000111392; -.
DR   HOGENOM; CLU_140744_1_0_1; -.
DR   InParanoid; Q8K064; -.
DR   OMA; PGNATGM; -.
DR   OrthoDB; 1612806at2759; -.
DR   PhylomeDB; Q8K064; -.
DR   TreeFam; TF105425; -.
DR   BioGRID-ORCS; 100038347; 3 hits in 73 CRISPR screens.
DR   ChiTaRS; Fam174b; mouse.
DR   PRO; PR:Q8K064; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q8K064; protein.
DR   Bgee; ENSMUSG00000078670; Expressed in interventricular septum and 243 other tissues.
DR   ExpressionAtlas; Q8K064; baseline and differential.
DR   Genevisible; Q8K064; MM.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0007030; P:Golgi organization; ISS:UniProtKB.
DR   InterPro; IPR009565; DUF1180.
DR   PANTHER; PTHR28607; PTHR28607; 1.
DR   Pfam; PF06679; DUF1180; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Golgi apparatus; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..153
FT                   /note="Membrane protein FAM174B"
FT                   /id="PRO_0000326115"
FT   TOPO_DOM        28..84
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        106..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          31..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        50
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        7
FT                   /note="Q -> P (in Ref. 2; BC034069/BC110691)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   153 AA;  16213 MW;  D55B26450857F2FB CRC64;
     MSALPPQPPP PLLLLLLALL AAPAALARRA ESASASQPEA EHQPPPGPGN ATQLGSGMAG
     GGSSNSSVDA VVTRISSLLR DLPTLKATVI VACAFSALLI ACLLLRVFRL GKRLKKTRKY
     DIITTPAERV EMAPLNEEDD EDEDSTVFDI KYR