F174C_MOUSE
ID F174C_MOUSE Reviewed; 108 AA.
AC Q9DAZ5; Q3THR0;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Protein FAM174C {ECO:0000305};
DE Flags: Precursor;
GN Name=Fam174c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=BALB/cJ, and C57BL/6J; TISSUE=Placenta, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93 AND SER-96, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, and
RC Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM174 family. {ECO:0000305}.
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DR EMBL; AK005397; BAB24000.1; -; mRNA.
DR EMBL; AK050606; BAC34337.1; -; mRNA.
DR EMBL; AK168176; BAE40136.1; -; mRNA.
DR EMBL; CH466553; EDL31584.1; -; Genomic_DNA.
DR EMBL; BC146018; AAI46019.1; -; mRNA.
DR EMBL; BC146020; AAI46021.1; -; mRNA.
DR CCDS; CCDS24012.1; -.
DR RefSeq; NP_081483.1; NM_027207.2.
DR AlphaFoldDB; Q9DAZ5; -.
DR STRING; 10090.ENSMUSP00000037758; -.
DR GlyGen; Q9DAZ5; 1 site.
DR iPTMnet; Q9DAZ5; -.
DR PhosphoSitePlus; Q9DAZ5; -.
DR jPOST; Q9DAZ5; -.
DR PaxDb; Q9DAZ5; -.
DR PeptideAtlas; Q9DAZ5; -.
DR PRIDE; Q9DAZ5; -.
DR Antibodypedia; 22649; 60 antibodies from 15 providers.
DR DNASU; 69770; -.
DR Ensembl; ENSMUST00000041882; ENSMUSP00000037758; ENSMUSG00000035595.
DR GeneID; 69770; -.
DR KEGG; mmu:69770; -.
DR UCSC; uc007gcf.1; mouse.
DR CTD; 55009; -.
DR MGI; MGI:1917020; Fam174c.
DR VEuPathDB; HostDB:ENSMUSG00000035595; -.
DR eggNOG; KOG3858; Eukaryota.
DR GeneTree; ENSGT00530000064649; -.
DR HOGENOM; CLU_141994_0_0_1; -.
DR InParanoid; Q9DAZ5; -.
DR OMA; IRACRLK; -.
DR OrthoDB; 1484610at2759; -.
DR TreeFam; TF339572; -.
DR BioGRID-ORCS; 69770; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q9DAZ5; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9DAZ5; protein.
DR Bgee; ENSMUSG00000035595; Expressed in retinal neural layer and 140 other tissues.
DR Genevisible; Q9DAZ5; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR009565; DUF1180.
DR PANTHER; PTHR28607; PTHR28607; 1.
DR Pfam; PF06679; DUF1180; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..108
FT /note="Protein FAM174C"
FT /id="PRO_0000393874"
FT TRANSMEM 47..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 83..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 93
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 7
FT /note="Missing (in Ref. 1; BAE40136)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 108 AA; 12374 MW; C282CEA2149A197F CRC64;
MALRMLLLLL LLWCSNPGSA ENSSLPGPPY NHTNGRLPDR DTGSAVLRLF YVITGLCGLI
SLYFLIRAFR LKKSQRRRYG LLTNTEEHEE MASQDSEEET VFETRNLR
