ID   F174_XENLA              Reviewed;         176 AA.
AC   Q640B5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Membrane protein FAM174;
DE   AltName: Full=Transmembrane protein 157;
DE   Flags: Precursor;
GN   Name=fam174;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAM174 family. {ECO:0000305}.
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DR   EMBL; BC082715; AAH82715.1; -; mRNA.
DR   RefSeq; NP_001088019.1; NM_001094550.1.
DR   RefSeq; XP_018093640.1; XM_018238151.1.
DR   AlphaFoldDB; Q640B5; -.
DR   DNASU; 494710; -.
DR   GeneID; 494710; -.
DR   KEGG; xla:494710; -.
DR   CTD; 494710; -.
DR   Xenbase; XB-GENE-6255337; fam174a.S.
DR   OrthoDB; 1507319at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 494710; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009565; DUF1180.
DR   PANTHER; PTHR28607; PTHR28607; 1.
DR   Pfam; PF06679; DUF1180; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..176
FT                   /note="Membrane protein FAM174"
FT                   /id="PRO_0000370363"
FT   TOPO_DOM        32..77
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..176
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          41..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   176 AA;  18599 MW;  F250036ACF66C77D CRC64;
     MGVDGYVSLC SVGGMLLALL ASSFISDGGC SVDAPTPSPA IPTGLASKKG SNSSTVDGGP
     LATVPSATSP NTPRTQRALV VLVLFSAAVV IYFVIRAVRT RIKNKKTRKY GVLDTNLGNM
     ELTPLEQDDD DDDTLFDSNQ PRSQLSLACI LQTPQFPAHV ISIRKGTSQC NALWVM