ID   F174_XENTR              Reviewed;         146 AA.
AC   A0JPB5; Q28H02;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Membrane protein FAM174;
DE   AltName: Full=Transmembrane protein 157;
DE   Flags: Precursor;
GN   Name=fam174; ORFNames=TEgg068m05.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Skin;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAM174 family. {ECO:0000305}.
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DR   EMBL; CR761132; CAJ82108.1; -; mRNA.
DR   EMBL; BC127343; AAI27344.1; -; mRNA.
DR   RefSeq; NP_001017124.1; NM_001017124.2.
DR   AlphaFoldDB; A0JPB5; -.
DR   SMR; A0JPB5; -.
DR   STRING; 8364.ENSXETP00000055455; -.
DR   PaxDb; A0JPB5; -.
DR   DNASU; 549878; -.
DR   Ensembl; ENSXETT00000062498; ENSXETP00000061472; ENSXETG00000026245.
DR   GeneID; 549878; -.
DR   KEGG; xtr:549878; -.
DR   CTD; 345757; -.
DR   Xenbase; XB-GENE-6538612; fam174a.
DR   eggNOG; ENOG502S4HB; Eukaryota.
DR   InParanoid; A0JPB5; -.
DR   OrthoDB; 1507319at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000026245; Expressed in testis and 13 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009565; DUF1180.
DR   PANTHER; PTHR28607; PTHR28607; 1.
DR   Pfam; PF06679; DUF1180; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..146
FT                   /note="Membrane protein FAM174"
FT                   /id="PRO_0000370364"
FT   TOPO_DOM        31..80
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..146
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          43..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..75
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        55
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   146 AA;  15499 MW;  E6E1548543F9E919 CRC64;
     MGCNSYMPQG SAGGMLLLLL AFCLLGDAGC ALSPPAASPA LPTAHLPLSP RKGSNSSTAA
     GAPLATVPSA TSPNKPRTQR ALVVLVLVSA AVIIYFVIRT MRTRRKNKKT RKYGVLDTNL
     GNMELTPLEQ DDEDDDTLFD ANQSRR