F177A_MOUSE
ID F177A_MOUSE Reviewed; 207 AA.
AC Q8BR63; Q9D9M7;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Protein FAM177A1;
GN Name=Fam177a1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65 AND THR-66, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the FAM177 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB24712.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK006713; BAB24712.1; ALT_INIT; mRNA.
DR EMBL; AK045530; BAC32408.1; -; mRNA.
DR EMBL; BC048158; AAH48158.1; -; mRNA.
DR EMBL; BC049669; AAH49669.1; -; mRNA.
DR CCDS; CCDS25913.1; -.
DR RefSeq; NP_001093586.1; NM_001100116.1.
DR RefSeq; NP_082803.1; NM_028527.1.
DR AlphaFoldDB; Q8BR63; -.
DR SMR; Q8BR63; -.
DR STRING; 10090.ENSMUSP00000137299; -.
DR iPTMnet; Q8BR63; -.
DR PhosphoSitePlus; Q8BR63; -.
DR SwissPalm; Q8BR63; -.
DR EPD; Q8BR63; -.
DR jPOST; Q8BR63; -.
DR MaxQB; Q8BR63; -.
DR PaxDb; Q8BR63; -.
DR PeptideAtlas; Q8BR63; -.
DR PRIDE; Q8BR63; -.
DR ProteomicsDB; 275975; -.
DR DNASU; 73385; -.
DR Ensembl; ENSMUST00000177768; ENSMUSP00000137299; ENSMUSG00000095595.
DR Ensembl; ENSMUST00000177978; ENSMUSP00000137377; ENSMUSG00000094103.
DR GeneID; 100101807; -.
DR GeneID; 73385; -.
DR KEGG; mmu:100101807; -.
DR KEGG; mmu:73385; -.
DR UCSC; uc007nog.1; mouse.
DR CTD; 100101807; -.
DR CTD; 73385; -.
DR MGI; MGI:1920635; 1700047I17Rik1.
DR VEuPathDB; HostDB:ENSMUSG00000094103; -.
DR VEuPathDB; HostDB:ENSMUSG00000095595; -.
DR eggNOG; ENOG502RYW3; Eukaryota.
DR GeneTree; ENSGT00390000016736; -.
DR HOGENOM; CLU_081605_0_0_1; -.
DR InParanoid; Q8BR63; -.
DR OMA; ITLYCAP; -.
DR OrthoDB; 1572938at2759; -.
DR PhylomeDB; Q8BR63; -.
DR TreeFam; TF326916; -.
DR BioGRID-ORCS; 100101807; 5 hits in 33 CRISPR screens.
DR BioGRID-ORCS; 73385; 2 hits in 32 CRISPR screens.
DR PRO; PR:Q8BR63; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8BR63; protein.
DR Bgee; ENSMUSG00000094103; Expressed in animal zygote and 52 other tissues.
DR Genevisible; Q8BR63; MM.
DR InterPro; IPR028260; FAM177.
DR PANTHER; PTHR31206; PTHR31206; 1.
DR Pfam; PF14774; FAM177; 1.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..207
FT /note="Protein FAM177A1"
FT /id="PRO_0000089886"
FT REGION 142..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 131..170
FT /evidence="ECO:0000255"
FT COMPBIAS 157..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q8N128"
FT MOD_RES 65
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 66
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 207 AA; 23578 MW; 61CEA19A6B58FBCD CRC64;
MERESGCAAA GETEAAAATA FRDATRQISN ERGFENVELG VMGKKKKVPR RVIHFVSGET
MEEYSTDEDE VDGLDKKDVL PTVDPTKLTW GPYLWFYMLR AATSTLSVCD FLGEKIASVL
GISTPKYQYA IDEYYRMKKE EEEEEEENRM SEEAERQYQQ NKLQADSIVQ TDQPETVSSS
FVNINFEMEE DCEAIKENKQ RPVSVPP
