F177B_HUMAN
ID F177B_HUMAN Reviewed; 158 AA.
AC A6PVY3; Q6ZUN8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Protein FAM177B;
GN Name=FAM177B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Peripheral blood;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6PVY3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6PVY3-2; Sequence=VSP_032476, VSP_032477;
CC -!- SIMILARITY: Belongs to the FAM177 family. {ECO:0000305}.
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DR EMBL; AK125494; BAC86182.1; -; mRNA.
DR EMBL; AL392172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS1535.2; -. [A6PVY3-1]
DR RefSeq; NP_001311009.1; NM_001324080.1. [A6PVY3-1]
DR RefSeq; NP_997351.2; NM_207468.2. [A6PVY3-1]
DR RefSeq; XP_016856768.1; XM_017001279.1. [A6PVY3-1]
DR RefSeq; XP_016856769.1; XM_017001280.1. [A6PVY3-1]
DR RefSeq; XP_016856770.1; XM_017001281.1. [A6PVY3-1]
DR RefSeq; XP_016856771.1; XM_017001282.1. [A6PVY3-1]
DR AlphaFoldDB; A6PVY3; -.
DR BioGRID; 134775; 3.
DR IntAct; A6PVY3; 2.
DR STRING; 9606.ENSP00000414451; -.
DR GlyGen; A6PVY3; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; A6PVY3; -.
DR PhosphoSitePlus; A6PVY3; -.
DR BioMuta; FAM177B; -.
DR MassIVE; A6PVY3; -.
DR PaxDb; A6PVY3; -.
DR PeptideAtlas; A6PVY3; -.
DR PRIDE; A6PVY3; -.
DR ProteomicsDB; 1727; -. [A6PVY3-1]
DR Antibodypedia; 71238; 31 antibodies from 11 providers.
DR DNASU; 400823; -.
DR Ensembl; ENST00000360827.6; ENSP00000354070.2; ENSG00000197520.11. [A6PVY3-1]
DR Ensembl; ENST00000391880.6; ENSP00000375752.2; ENSG00000197520.11. [A6PVY3-2]
DR Ensembl; ENST00000445590.4; ENSP00000414451.2; ENSG00000197520.11. [A6PVY3-1]
DR GeneID; 400823; -.
DR KEGG; hsa:400823; -.
DR MANE-Select; ENST00000445590.4; ENSP00000414451.2; NM_001394345.1; NP_001381274.1.
DR UCSC; uc009xeb.4; human. [A6PVY3-1]
DR CTD; 400823; -.
DR GeneCards; FAM177B; -.
DR HGNC; HGNC:34395; FAM177B.
DR HPA; ENSG00000197520; Tissue enriched (stomach).
DR neXtProt; NX_A6PVY3; -.
DR OpenTargets; ENSG00000197520; -.
DR PharmGKB; PA162387394; -.
DR VEuPathDB; HostDB:ENSG00000197520; -.
DR eggNOG; ENOG502S4DM; Eukaryota.
DR GeneTree; ENSGT00390000016736; -.
DR HOGENOM; CLU_081605_1_0_1; -.
DR InParanoid; A6PVY3; -.
DR OMA; RRIIHFV; -.
DR OrthoDB; 1572938at2759; -.
DR PhylomeDB; A6PVY3; -.
DR TreeFam; TF326916; -.
DR PathwayCommons; A6PVY3; -.
DR SignaLink; A6PVY3; -.
DR BioGRID-ORCS; 400823; 21 hits in 1063 CRISPR screens.
DR ChiTaRS; FAM177B; human.
DR GenomeRNAi; 400823; -.
DR Pharos; A6PVY3; Tdark.
DR PRO; PR:A6PVY3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A6PVY3; protein.
DR Bgee; ENSG00000197520; Expressed in gall bladder and 105 other tissues.
DR ExpressionAtlas; A6PVY3; baseline and differential.
DR InterPro; IPR028260; FAM177.
DR PANTHER; PTHR31206; PTHR31206; 1.
DR Pfam; PF14774; FAM177; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..158
FT /note="Protein FAM177B"
FT /id="PRO_0000325915"
FT REGION 36..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..50
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 81..120
FT /note="TCEFLGGRFAVFFGLTQPKYQYVLNEFYRIQNKKSDNKSE -> MLSLQATL
FT LLKAEKEGLKQLLRSLSGCMEEFLMWVLVTLD (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032476"
FT VAR_SEQ 121..158
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032477"
FT VARIANT 3
FT /note="I -> S (in dbSNP:rs2378607)"
FT /id="VAR_039953"
FT VARIANT 143
FT /note="Q -> R (in dbSNP:rs6683071)"
FT /id="VAR_054090"
SQ SEQUENCE 158 AA; 18145 MW; 89E4532266015349 CRC64;
MEIDGFQQLD LEKSVPSKKT TPKRIIHFVD GDIMEEYSTE EEEEEEKEEQ STNSTLDPSK
LSWGPYLRFW AGRIASTSFS TCEFLGGRFA VFFGLTQPKY QYVLNEFYRI QNKKSDNKSE
RRGSKAQAAE VPNEKCHLEA GVQEYGTIQQ DVTEAIPQ
