F178B_MOUSE
ID F178B_MOUSE Reviewed; 464 AA.
AC Q24JP3; Q3URT9; Q80VJ7; Q9DA00;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Protein FAM178B {ECO:0000305};
GN Name=Fam178b {ECO:0000312|MGI:MGI:3026913};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=129/Sv X 129SvCp; TISSUE=Embryonic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q24JP3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q24JP3-2; Sequence=VSP_031637;
CC Name=3;
CC IsoId=Q24JP3-3; Sequence=VSP_031639, VSP_031640;
CC Name=4;
CC IsoId=Q24JP3-4; Sequence=VSP_031638;
CC -!- SIMILARITY: Belongs to the FAM178 family. {ECO:0000305}.
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DR EMBL; AK006300; BAB24515.1; -; mRNA.
DR EMBL; AK141223; BAE24598.1; -; mRNA.
DR EMBL; AC084389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC084391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC050210; AAH50210.1; -; mRNA.
DR EMBL; BC114576; AAI14577.1; -; mRNA.
DR RefSeq; NP_001119518.1; NM_001126046.1.
DR RefSeq; NP_082233.1; NM_027957.1. [Q24JP3-4]
DR RefSeq; NP_958753.2; NM_201365.2.
DR RefSeq; XP_006496185.1; XM_006496122.3. [Q24JP3-4]
DR RefSeq; XP_011236857.1; XM_011238555.2. [Q24JP3-4]
DR AlphaFoldDB; Q24JP3; -.
DR STRING; 10090.ENSMUSP00000132846; -.
DR PhosphoSitePlus; Q24JP3; -.
DR PaxDb; Q24JP3; -.
DR PRIDE; Q24JP3; -.
DR ProteomicsDB; 275976; -. [Q24JP3-1]
DR ProteomicsDB; 275977; -. [Q24JP3-2]
DR ProteomicsDB; 275978; -. [Q24JP3-3]
DR ProteomicsDB; 275979; -. [Q24JP3-4]
DR DNASU; 381337; -.
DR GeneID; 381337; -.
DR KEGG; mmu:381337; -.
DR UCSC; uc007aqu.2; mouse. [Q24JP3-4]
DR CTD; 51252; -.
DR MGI; MGI:3026913; Fam178b.
DR eggNOG; ENOG502RXJ9; Eukaryota.
DR InParanoid; Q24JP3; -.
DR OrthoDB; 713086at2759; -.
DR PhylomeDB; Q24JP3; -.
DR BioGRID-ORCS; 381337; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Fam178b; mouse.
DR PRO; PR:Q24JP3; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q24JP3; protein.
DR InterPro; IPR044276; CANIN_dom.
DR InterPro; IPR026161; FAM178.
DR PANTHER; PTHR16046; PTHR16046; 2.
DR Pfam; PF14816; CANIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..464
FT /note="Protein FAM178B"
FT /id="PRO_0000320194"
FT VAR_SEQ 1..345
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031637"
FT VAR_SEQ 1..319
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031638"
FT VAR_SEQ 307..320
FT /note="QLRSQLSLVIIARM -> WVLLNHIPRDLSRI (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_031639"
FT VAR_SEQ 321..464
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_031640"
FT CONFLICT 184
FT /note="S -> G (in Ref. 3; AAH50210)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 464 AA; 52581 MW; 40FC2D9B8F8B86FB CRC64;
MASPSQQAGT PEISSGSSQC YINNLDYLLQ EKRMLVEKFS VSLQVISPVH PGETVFLPRR
HPLPCFLDSS RLKPHSPLEE LFLRSSLPEQ LSFLHNGLLS NLYLHAADCP QPLLQWLFQL
LTWPPETSSR AFGLLWDLSI DGLFRQPDED MHFWCPSLQE VKEVFSSLGA YNPALYPQGP
FQHSARVLES EASLDSQDPP QEVALDIKLN YIYKFLTLCL LVRPVSYTDA SILDLMELLC
RAGLDVGLCL LPKTDLQQLL LLLLERIQEW PGKLQPLCCA LSWVSDHHHN LLALVQFFLD
VTPRGRQLRS QLSLVIIARM LGQQESLPFS AEKTQLALLS QLLSLMRPSS LRQCLGIETL
PSSLGQHSKA SAELDYKVCY LCHSLLTLAG VVVSSQDITP NQWGELQLLC MQLDRHISTH
IRESPQAMHR TKLKDLATQT YIRWQDLLAH CQPQGQYFSP WKDI
