ID   F17_VAR67               Reviewed;         101 AA.
AC   P0DON5; P33875;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   03-AUG-2022, entry version 9.
DE   RecName: Full=Phosphoprotein F17;
GN   ORFNames=C21R, F17R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8109158; DOI=10.1016/0168-1702(93)90093-3;
RA   Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V.,
RA   Sandakhchiev L.S.;
RT   "Analysis of the nucleotide sequence of a 43 kbp segment of the genome of
RT   variola virus India-1967 strain.";
RL   Virus Res. 30:239-258(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Plays an essential role in virion assembly and morphogenesis.
CC       Also plays a role in the inhibition of host immune response by
CC       dysregulating mTOR. Sequesters host RICTOR and RPTOR, thereby
CC       disrupting mTORC1 and mTORC2 crosstalk. In turn, blocks the host
CC       antiviral response in part through mTOR-dependent degradation of cGAS,
CC       the primary poxvirus sensor. {ECO:0000250|UniProtKB:P07396}.
CC   -!- SUBUNIT: Self-associates to form high molecular-weight forms. Interacts
CC       with protein A30. Interacts with host RICTOR and RPTOR; these
CC       interactions disrupt the mTORC1 and mTORC2 crosstalk.
CC       {ECO:0000250|UniProtKB:P07396}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P07396}. Note=Major
CC       component of the virion comprising about 10% of the virion mass.
CC       {ECO:0000250|UniProtKB:P07396}.
CC   -!- PTM: Phosphorylated on two serines. While these phosphorylations do not
CC       play a role in virion assembly; they are essential for the interaction
CC       with host RICTOR and RPTOR. {ECO:0000250|UniProtKB:P07396}.
CC   -!- SIMILARITY: Belongs to the poxviridae F17 protein family.
CC       {ECO:0000305}.
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DR   EMBL; X69198; CAA48982.1; -; Genomic_DNA.
DR   PIR; C36841; C36841.
DR   RefSeq; NP_042085.1; NC_001611.1.
DR   GeneID; 1486578; -.
DR   KEGG; vg:1486578; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0019082; P:viral protein processing; IEA:InterPro.
DR   InterPro; IPR006854; Phosphoprotein_F17.
DR   Pfam; PF04767; Pox_F17; 1.
DR   PIRSF; PIRSF003688; VAC_PP; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Reference proteome; Virion.
FT   CHAIN           1..101
FT                   /note="Phosphoprotein F17"
FT                   /id="PRO_0000099522"
FT   REGION          48..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         53
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P07396"
FT   MOD_RES         62
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P07396"
SQ   SEQUENCE   101 AA;  11337 MW;  B8160F92D14BF2B1 CRC64;
     MNSHFASAHT PFYINTKEGR YLVLKAVKVC DVRTVEFEGS KASCVLKVDK PSSPASERRP
     SSPSRCERMN NPGKQVPFMR TDMLQNMFAA NRDNVASRLL S