ID   F180A_HUMAN             Reviewed;         173 AA.
AC   Q6UWF9; B2RP85;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Protein FAM180A;
DE   Flags: Precursor;
GN   Name=FAM180A; ORFNames=UNQ1940/PRO4423;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA   Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA   Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA   Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA   Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA   Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA   Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA   Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA   Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA   Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA   Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA   Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA   Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAM180 family. {ECO:0000305}.
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DR   EMBL; AY358803; AAQ89163.1; -; mRNA.
DR   EMBL; AK290250; BAF82939.1; -; mRNA.
DR   EMBL; AK297754; BAG60104.1; -; mRNA.
DR   EMBL; CH236950; EAL24057.1; -; Genomic_DNA.
DR   EMBL; BC137311; AAI37312.1; -; mRNA.
DR   EMBL; BC137312; AAI37313.1; -; mRNA.
DR   CCDS; CCDS5841.1; -.
DR   RefSeq; NP_995327.1; NM_205855.3.
DR   RefSeq; XP_006716046.1; XM_006715983.3.
DR   AlphaFoldDB; Q6UWF9; -.
DR   STRING; 9606.ENSP00000342336; -.
DR   PhosphoSitePlus; Q6UWF9; -.
DR   BioMuta; FAM180A; -.
DR   DMDM; 74738086; -.
DR   jPOST; Q6UWF9; -.
DR   MassIVE; Q6UWF9; -.
DR   PaxDb; Q6UWF9; -.
DR   PeptideAtlas; Q6UWF9; -.
DR   PRIDE; Q6UWF9; -.
DR   ProteomicsDB; 67477; -.
DR   Antibodypedia; 18164; 11 antibodies from 8 providers.
DR   DNASU; 389558; -.
DR   Ensembl; ENST00000338588.8; ENSP00000342336.3; ENSG00000189320.9.
DR   Ensembl; ENST00000415751.1; ENSP00000395467.1; ENSG00000189320.9.
DR   Ensembl; ENST00000444083.5; ENSP00000406553.1; ENSG00000189320.9.
DR   GeneID; 389558; -.
DR   KEGG; hsa:389558; -.
DR   MANE-Select; ENST00000338588.8; ENSP00000342336.3; NM_205855.4; NP_995327.1.
DR   UCSC; uc003vtd.4; human.
DR   CTD; 389558; -.
DR   DisGeNET; 389558; -.
DR   GeneCards; FAM180A; -.
DR   HGNC; HGNC:33773; FAM180A.
DR   HPA; ENSG00000189320; Tissue enhanced (gallbladder, heart muscle).
DR   neXtProt; NX_Q6UWF9; -.
DR   OpenTargets; ENSG00000189320; -.
DR   PharmGKB; PA162387559; -.
DR   VEuPathDB; HostDB:ENSG00000189320; -.
DR   eggNOG; ENOG502S335; Eukaryota.
DR   GeneTree; ENSGT00940000154479; -.
DR   HOGENOM; CLU_105099_0_0_1; -.
DR   InParanoid; Q6UWF9; -.
DR   OMA; MCWKTLL; -.
DR   OrthoDB; 1243722at2759; -.
DR   PhylomeDB; Q6UWF9; -.
DR   TreeFam; TF333387; -.
DR   PathwayCommons; Q6UWF9; -.
DR   BioGRID-ORCS; 389558; 7 hits in 1066 CRISPR screens.
DR   GenomeRNAi; 389558; -.
DR   Pharos; Q6UWF9; Tdark.
DR   PRO; PR:Q6UWF9; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q6UWF9; protein.
DR   Bgee; ENSG00000189320; Expressed in ascending aorta and 86 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029170; FAM180.
DR   PANTHER; PTHR34034; PTHR34034; 1.
DR   Pfam; PF15173; FAM180; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..173
FT                   /note="Protein FAM180A"
FT                   /id="PRO_0000317516"
FT   VARIANT         96
FT                   /note="V -> I (in dbSNP:rs3112374)"
FT                   /id="VAR_054081"
SQ   SEQUENCE   173 AA;  19733 MW;  A332C95994D0AB85 CRC64;
     MHWKMLLLLL LYYNAEASMC HRWSRAVLFP AAHRPKRSSS LPLNPVLQTS LEEVELLYEF
     LLAELEISPD LQISIKDEEL ASLRKASDFR TVCNNVIPKS IPDIRRLSAS LSSHPGILKK
     EDFERTVLTL AYTAYRTALS HGHQKDIWAQ SLVSLFQALR HDLMRSSQPG VPP