ID   F180A_MOUSE             Reviewed;         173 AA.
AC   Q8BR21;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Protein FAM180A;
DE   Flags: Precursor;
GN   Name=Fam180a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Inner ear;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAM180 family. {ECO:0000305}.
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DR   EMBL; AK045849; BAC32511.1; -; mRNA.
DR   EMBL; AK157966; BAE34287.1; -; mRNA.
DR   EMBL; BC064033; AAH64033.1; -; mRNA.
DR   CCDS; CCDS20001.1; -.
DR   RefSeq; NP_775551.1; NM_173375.1.
DR   AlphaFoldDB; Q8BR21; -.
DR   STRING; 10090.ENSMUSP00000051206; -.
DR   PhosphoSitePlus; Q8BR21; -.
DR   PaxDb; Q8BR21; -.
DR   PRIDE; Q8BR21; -.
DR   Antibodypedia; 18164; 11 antibodies from 8 providers.
DR   DNASU; 208164; -.
DR   Ensembl; ENSMUST00000051176; ENSMUSP00000051206; ENSMUSG00000047420.
DR   GeneID; 208164; -.
DR   KEGG; mmu:208164; -.
DR   UCSC; uc009bir.1; mouse.
DR   CTD; 389558; -.
DR   MGI; MGI:3039626; Fam180a.
DR   VEuPathDB; HostDB:ENSMUSG00000047420; -.
DR   eggNOG; ENOG502S335; Eukaryota.
DR   GeneTree; ENSGT00940000154479; -.
DR   HOGENOM; CLU_105099_0_0_1; -.
DR   InParanoid; Q8BR21; -.
DR   OMA; MCWKTLL; -.
DR   OrthoDB; 1243722at2759; -.
DR   PhylomeDB; Q8BR21; -.
DR   TreeFam; TF333387; -.
DR   BioGRID-ORCS; 208164; 1 hit in 73 CRISPR screens.
DR   PRO; PR:Q8BR21; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q8BR21; protein.
DR   Bgee; ENSMUSG00000047420; Expressed in humerus cartilage element and 87 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029170; FAM180.
DR   PANTHER; PTHR34034; PTHR34034; 1.
DR   Pfam; PF15173; FAM180; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..173
FT                   /note="Protein FAM180A"
FT                   /id="PRO_0000317517"
SQ   SEQUENCE   173 AA;  19449 MW;  FBD8FDB8C803699B CRC64;
     MSWKALTILL VFSSTQATAS CRWSRAALFP AAHRPKRSLS LPLNPVLQTS LEEVELLYEL
     LLAEIEISPD LEISIKDEEL ASLRKALSFH SICNNIIPKR IPDIRRLSAN LANHPGILKK
     EDFERITLTL AYTAYRTALS EGHQKDIWAQ SLISLFQALR HDLMRSSSPA VSS