ID   F180B_HUMAN             Reviewed;         183 AA.
AC   Q6P0A1; A0A0B4J243;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 3.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Protein FAM180B;
DE   Flags: Precursor;
GN   Name=FAM180B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1] {ECO:0000312|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PNS;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q6P0A1; Q8TAZ6: CMTM2; NbExp=3; IntAct=EBI-17856026, EBI-2339374;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAM180 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH65704.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC104942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC065704; AAH65704.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001157851.1; NM_001164379.1.
DR   AlphaFoldDB; Q6P0A1; -.
DR   BioGRID; 134442; 1.
DR   IntAct; Q6P0A1; 1.
DR   STRING; 9606.ENSP00000443133; -.
DR   iPTMnet; Q6P0A1; -.
DR   PhosphoSitePlus; Q6P0A1; -.
DR   BioMuta; FAM180B; -.
DR   MassIVE; Q6P0A1; -.
DR   PaxDb; Q6P0A1; -.
DR   PeptideAtlas; Q6P0A1; -.
DR   PRIDE; Q6P0A1; -.
DR   ProteomicsDB; 66812; -.
DR   Antibodypedia; 26836; 8 antibodies from 7 providers.
DR   DNASU; 399888; -.
DR   Ensembl; ENST00000538490.3; ENSP00000443133.2; ENSG00000196666.6.
DR   Ensembl; ENST00000644402.4; ENSP00000496127.2; ENSG00000284938.4.
DR   GeneID; 399888; -.
DR   KEGG; hsa:399888; -.
DR   MANE-Select; ENST00000538490.3; ENSP00000443133.2; NM_001164379.3; NP_001157851.1.
DR   CTD; 399888; -.
DR   DisGeNET; 399888; -.
DR   GeneCards; FAM180B; -.
DR   HGNC; HGNC:34451; FAM180B.
DR   HPA; ENSG00000196666; Tissue enhanced (brain, breast, skin).
DR   neXtProt; NX_Q6P0A1; -.
DR   OpenTargets; ENSG00000196666; -.
DR   PharmGKB; PA162387572; -.
DR   VEuPathDB; HostDB:ENSG00000196666; -.
DR   eggNOG; ENOG502S953; Eukaryota.
DR   GeneTree; ENSGT00940000154479; -.
DR   HOGENOM; CLU_113562_0_0_1; -.
DR   InParanoid; Q6P0A1; -.
DR   OMA; WALILDP; -.
DR   OrthoDB; 1435517at2759; -.
DR   PhylomeDB; Q6P0A1; -.
DR   TreeFam; TF333387; -.
DR   PathwayCommons; Q6P0A1; -.
DR   SignaLink; Q6P0A1; -.
DR   BioGRID-ORCS; 399888; 13 hits in 317 CRISPR screens.
DR   GenomeRNAi; 399888; -.
DR   Pharos; Q6P0A1; Tdark.
DR   PRO; PR:Q6P0A1; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q6P0A1; protein.
DR   Bgee; ENSG00000196666; Expressed in calcaneal tendon and 91 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029170; FAM180.
DR   PANTHER; PTHR34034; PTHR34034; 1.
DR   Pfam; PF15173; FAM180; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..183
FT                   /note="Protein FAM180B"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000349380"
FT   VARIANT         145
FT                   /note="A -> T (in dbSNP:rs4486587)"
FT                   /id="VAR_046379"
SQ   SEQUENCE   183 AA;  20302 MW;  E78213BF993CA2DF CRC64;
     MAATLQFLVC LVVAICLLSG VTTTQPHAGQ PMDSTSVGGG LQEPEAPEVM FELLWAGLEL
     DVMGQLHIQD EELASTHPGR RLRLLLQHHV PSDLEGTEQW LQQLQDLRKG PPLSTWDFEH
     LLLTGLSCVY RLHAASEAEE RGRWAQVFAL LAQETLWDLC KGFCPQDRPP SLGSWASILD
     PFP