ID   F181B_HUMAN             Reviewed;         426 AA.
AC   A6NEQ2; B2RWP1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Protein FAM181B;
GN   Name=FAM181B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the FAM181 family. {ECO:0000305}.
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DR   EMBL; AP002796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471076; EAW75073.1; -; Genomic_DNA.
DR   EMBL; BC150621; AAI50622.1; -; mRNA.
DR   CCDS; CCDS31648.1; -.
DR   RefSeq; NP_787081.2; NM_175885.3.
DR   PDB; 6SEO; X-ray; 2.55 A; L=220-235.
DR   PDBsum; 6SEO; -.
DR   AlphaFoldDB; A6NEQ2; -.
DR   SMR; A6NEQ2; -.
DR   STRING; 9606.ENSP00000365295; -.
DR   iPTMnet; A6NEQ2; -.
DR   PhosphoSitePlus; A6NEQ2; -.
DR   BioMuta; FAM181B; -.
DR   EPD; A6NEQ2; -.
DR   MassIVE; A6NEQ2; -.
DR   PaxDb; A6NEQ2; -.
DR   PeptideAtlas; A6NEQ2; -.
DR   PRIDE; A6NEQ2; -.
DR   ProteomicsDB; 1002; -.
DR   Antibodypedia; 57727; 32 antibodies from 11 providers.
DR   DNASU; 220382; -.
DR   Ensembl; ENST00000329203.5; ENSP00000365295.2; ENSG00000182103.5.
DR   GeneID; 220382; -.
DR   KEGG; hsa:220382; -.
DR   MANE-Select; ENST00000329203.5; ENSP00000365295.2; NM_175885.4; NP_787081.2.
DR   UCSC; uc001ozp.4; human.
DR   CTD; 220382; -.
DR   GeneCards; FAM181B; -.
DR   HGNC; HGNC:28512; FAM181B.
DR   HPA; ENSG00000182103; Tissue enriched (brain).
DR   neXtProt; NX_A6NEQ2; -.
DR   OpenTargets; ENSG00000182103; -.
DR   PharmGKB; PA162387593; -.
DR   VEuPathDB; HostDB:ENSG00000182103; -.
DR   eggNOG; ENOG502QS8E; Eukaryota.
DR   GeneTree; ENSGT00940000154730; -.
DR   HOGENOM; CLU_055561_0_0_1; -.
DR   InParanoid; A6NEQ2; -.
DR   OMA; PNFFTDC; -.
DR   OrthoDB; 950012at2759; -.
DR   PhylomeDB; A6NEQ2; -.
DR   TreeFam; TF333276; -.
DR   PathwayCommons; A6NEQ2; -.
DR   BioGRID-ORCS; 220382; 7 hits in 1071 CRISPR screens.
DR   GenomeRNAi; 220382; -.
DR   Pharos; A6NEQ2; Tdark.
DR   PRO; PR:A6NEQ2; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; A6NEQ2; protein.
DR   Bgee; ENSG00000182103; Expressed in endothelial cell and 112 other tissues.
DR   Genevisible; A6NEQ2; HS.
DR   InterPro; IPR029359; FAM181.
DR   PANTHER; PTHR33766; PTHR33766; 1.
DR   Pfam; PF15238; FAM181; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome.
FT   CHAIN           1..426
FT                   /note="Protein FAM181B"
FT                   /id="PRO_0000324302"
FT   REGION          106..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          226..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         186
FT                   /note="V -> L (in dbSNP:rs986097)"
FT                   /id="VAR_039694"
FT   VARIANT         367
FT                   /note="R -> P (in dbSNP:rs6592081)"
FT                   /id="VAR_039695"
FT   CONFLICT        394
FT                   /note="D -> N (in Ref. 3; AAI50622)"
FT                   /evidence="ECO:0000305"
FT   HELIX           222..224
FT                   /evidence="ECO:0007829|PDB:6SEO"
FT   HELIX           229..231
FT                   /evidence="ECO:0007829|PDB:6SEO"
SQ   SEQUENCE   426 AA;  42657 MW;  3B3E0116C8029D16 CRC64;
     MAVQAALLST HPFVPFGFGG SPDGLGGAFG ALDKGCCFED DETGAPAGAL LSGAEGGDVR
     EATRDLLSFI DSASSNIKLA LDKPGKSKRK VNHRKYLQKQ IKRCSGLMGA APPGPPSPSA
     ADTPAKRPLA APSAPTVAAP AHGKAAPRRE ASQAAAAASL QSRSLAALFD SLRHVPGGAE
     PAGGEVAAPA AGLGGAGTGG AGGDVAGPAG ATAIPGARKV PLRARNLPPS FFTEPSRAGG
     GGCGPSGPDV SLGDLEKGAE AVEFFELLGP DYGAGTEAAV LLAAEPLDVF PAGASVLRGP
     PELEPGLFEP PPAVVGNLLY PEPWSVPGCS PTKKSPLTAP RGGLTLNEPL SPLYPAAADS
     PGGEDGRGHL ASFAPFFPDC ALPPPPPPHQ VSYDYSAGYS RTAYSSLWRS DGVWEGAPGE
     EGAHRD