F181B_MOUSE
ID F181B_MOUSE Reviewed; 417 AA.
AC Q80VF6; Q3URI7; Q9JJD9;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Protein FAM181B;
GN Name=Fam181b; ORFNames=MNCb-1231;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-417 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80VF6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80VF6-2; Sequence=VSP_032190, VSP_032191;
CC -!- SIMILARITY: Belongs to the FAM181 family. {ECO:0000305}.
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DR EMBL; AB041569; BAA95053.1; -; mRNA.
DR EMBL; BC043329; AAH43329.1; -; mRNA.
DR EMBL; AK141493; BAE24701.1; -; mRNA.
DR AlphaFoldDB; Q80VF6; -.
DR PhosphoSitePlus; Q80VF6; -.
DR PRIDE; Q80VF6; -.
DR ProteomicsDB; 275980; -. [Q80VF6-1]
DR ProteomicsDB; 275981; -. [Q80VF6-2]
DR UCSC; uc009iim.1; mouse. [Q80VF6-1]
DR MGI; MGI:1930951; Fam181b.
DR InParanoid; Q80VF6; -.
DR ChiTaRS; Fam181b; mouse.
DR PRO; PR:Q80VF6; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q80VF6; protein.
DR InterPro; IPR029359; FAM181.
DR PANTHER; PTHR33766; PTHR33766; 1.
DR Pfam; PF15238; FAM181; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..417
FT /note="Protein FAM181B"
FT /id="PRO_0000324303"
FT REGION 104..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 235..330
FT /note="GGASGVPSGQGVSLGDLEKGAEAVEFFELLAPDFGSGNDSGVLMAADPLDPF
FT PAGATVLRGPLELESGPFEQPAMVGNLLYPEPWNTPSCPQTKKP -> WLAPAASHRAR
FT A (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_032190"
FT VAR_SEQ 331..417
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_032191"
FT CONFLICT 46
FT /note="S -> T (in Ref. 1; BAA95053)"
FT /evidence="ECO:0000305"
FT CONFLICT 102
FT /note="K -> R (in Ref. 1; BAA95053)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 417 AA; 42437 MW; 95FFFCF49351C6D8 CRC64;
MAVQAALLSS HPFIPFGFGG SADGLVSAFG SLDKGCCFED DESGASAGAL LSGSEGGDVR
EATRDLLSFI DSASSNIKLA LDKPGKSKRK VNHRKYLQKQ IKRCSGLMGT APPRPASPSA
ADAPAKRPPG APTVATPAHC KAAPRREATQ AAAAASLQSR SLAALFDSLR HIPGGAETAG
GAEAVSVPGL GAASAVGDGA GTAVSSVAPG TRKVPLRARN LPPSFFTEPS RVGCGGASGV
PSGQGVSLGD LEKGAEAVEF FELLAPDFGS GNDSGVLMAA DPLDPFPAGA TVLRGPLELE
SGPFEQPAMV GNLLYPEPWN TPSCPQTKKP PVAGVRGGVT LNEPVRLLYP TALDSPGGED
APALSSFTPF FPDCALPPPH QVSYDYSAGY SRAVYPSLWR PDGVWEGASG EEGGHPD
