F183B_MOUSE
ID F183B_MOUSE Reviewed; 135 AA.
AC Q5NC57; Q3TZB7; Q9CXW5;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Protein FAM183B;
GN Name=Fam183b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Head, and Inner ear;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP INDUCTION.
RX PubMed=27914912; DOI=10.1016/j.ydbio.2016.11.019;
RA Stauber M., Weidemann M., Dittrich-Breiholz O., Lobschat K., Alten L.,
RA Mai M., Beckers A., Kracht M., Gossler A.;
RT "Identification of FOXJ1 effectors during ciliogenesis in the foetal
RT respiratory epithelium and embryonic left-right organiser of the mouse.";
RL Dev. Biol. 423:170-188(2017).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000269|PubMed:27914912}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5NC57-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5NC57-2; Sequence=VSP_034207;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in tissues containing
CC motile cilia. {ECO:0000269|PubMed:27914912}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the developing fetal lung epithelium
CC and embryonic ventral node (at protein level).
CC {ECO:0000269|PubMed:27914912}.
CC -!- INDUCTION: Expression is activated by FOXJ1 and NOTO.
CC {ECO:0000269|PubMed:27914912}.
CC -!- SIMILARITY: Belongs to the FAM183 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB29057.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE34292.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAI25624.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAI25625.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK013920; BAB29057.1; ALT_INIT; mRNA.
DR EMBL; AK157972; BAE34292.1; ALT_INIT; mRNA.
DR EMBL; AL662903; CAI25624.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL662903; CAI25625.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC117741; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC126964; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS48807.2; -. [Q5NC57-2]
DR CCDS; CCDS48808.2; -. [Q5NC57-1]
DR RefSeq; NP_001156350.1; NM_001162878.1. [Q5NC57-2]
DR RefSeq; NP_083559.1; NM_029283.1. [Q5NC57-1]
DR AlphaFoldDB; Q5NC57; -.
DR STRING; 10090.ENSMUSP00000091708; -.
DR PhosphoSitePlus; Q5NC57; -.
DR MaxQB; Q5NC57; -.
DR PaxDb; Q5NC57; -.
DR PRIDE; Q5NC57; -.
DR ProteomicsDB; 267686; -. [Q5NC57-1]
DR ProteomicsDB; 267687; -. [Q5NC57-2]
DR Antibodypedia; 77971; 6 antibodies from 3 providers.
DR Ensembl; ENSMUST00000060581; ENSMUSP00000051960; ENSMUSG00000049154. [Q5NC57-2]
DR Ensembl; ENSMUST00000094156; ENSMUSP00000091708; ENSMUSG00000049154. [Q5NC57-1]
DR GeneID; 75429; -.
DR KEGG; mmu:75429; -.
DR UCSC; uc011xvi.1; mouse. [Q5NC57-2]
DR CTD; 75429; -.
DR MGI; MGI:1922679; Fam183b.
DR VEuPathDB; HostDB:ENSMUSG00000049154; -.
DR eggNOG; ENOG502RZSS; Eukaryota.
DR GeneTree; ENSGT00390000006224; -.
DR InParanoid; Q5NC57; -.
DR OMA; SQEIGWM; -.
DR BioGRID-ORCS; 75429; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Fam183b; mouse.
DR PRO; PR:Q5NC57; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5NC57; protein.
DR Bgee; ENSMUSG00000049154; Expressed in spermatid and 87 other tissues.
DR ExpressionAtlas; Q5NC57; baseline and differential.
DR GO; GO:0005813; C:centrosome; IDA:MGI.
DR GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB.
DR GO; GO:0097546; C:ciliary base; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR InterPro; IPR029214; FAM183.
DR PANTHER; PTHR33865; PTHR33865; 1.
DR Pfam; PF14886; FAM183; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..135
FT /note="Protein FAM183B"
FT /id="PRO_0000340272"
FT REGION 76..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 45..64
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034207"
FT CONFLICT 32
FT /note="K -> E (in Ref. 1; BAE34292)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 135 AA; 16125 MW; 7EC94171A1026E57 CRC64;
MAGRVGQMKN QDEVHQNQIL RELFLKELRA QKLYTQYHVN PLRKVHTITR KPMSWHDNLE
EPEDAKFLNL IHHAAQGPKK KYSETQTEAQ EIGWDPNPLI NPDRQDHRLN HFRVYHDITL
YKAKLWSLGE DDHQK
