F184B_HUMAN
ID F184B_HUMAN Reviewed; 1060 AA.
AC Q9ULE4;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein FAM184B;
GN Name=FAM184B; Synonyms=KIAA1276;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-1042.
RC TISSUE=Brain;
RX PubMed=10574462; DOI=10.1093/dnares/6.5.337;
RA Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:337-345(1999).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- SIMILARITY: Belongs to the FAM184 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA86590.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB033102; BAA86590.1; ALT_INIT; mRNA.
DR EMBL; AC005768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS47033.1; -.
DR RefSeq; NP_056503.1; NM_015688.1.
DR AlphaFoldDB; Q9ULE4; -.
DR SMR; Q9ULE4; -.
DR BioGRID; 118030; 4.
DR IntAct; Q9ULE4; 1.
DR STRING; 9606.ENSP00000265018; -.
DR iPTMnet; Q9ULE4; -.
DR PhosphoSitePlus; Q9ULE4; -.
DR BioMuta; FAM184B; -.
DR DMDM; 296439355; -.
DR EPD; Q9ULE4; -.
DR jPOST; Q9ULE4; -.
DR MassIVE; Q9ULE4; -.
DR MaxQB; Q9ULE4; -.
DR PaxDb; Q9ULE4; -.
DR PeptideAtlas; Q9ULE4; -.
DR PRIDE; Q9ULE4; -.
DR ProteomicsDB; 85010; -.
DR Antibodypedia; 23092; 27 antibodies from 8 providers.
DR DNASU; 27146; -.
DR Ensembl; ENST00000265018.4; ENSP00000265018.3; ENSG00000047662.5.
DR GeneID; 27146; -.
DR KEGG; hsa:27146; -.
DR MANE-Select; ENST00000265018.4; ENSP00000265018.3; NM_015688.2; NP_056503.1.
DR UCSC; uc003gpm.5; human.
DR CTD; 27146; -.
DR DisGeNET; 27146; -.
DR GeneCards; FAM184B; -.
DR HGNC; HGNC:29235; FAM184B.
DR HPA; ENSG00000047662; Tissue enhanced (brain, retina, skeletal muscle).
DR neXtProt; NX_Q9ULE4; -.
DR OpenTargets; ENSG00000047662; -.
DR PharmGKB; PA164719809; -.
DR VEuPathDB; HostDB:ENSG00000047662; -.
DR eggNOG; ENOG502RRRX; Eukaryota.
DR GeneTree; ENSGT00530000063669; -.
DR HOGENOM; CLU_005374_0_0_1; -.
DR InParanoid; Q9ULE4; -.
DR OMA; PQELDCQ; -.
DR OrthoDB; 170922at2759; -.
DR PhylomeDB; Q9ULE4; -.
DR TreeFam; TF316006; -.
DR PathwayCommons; Q9ULE4; -.
DR SignaLink; Q9ULE4; -.
DR BioGRID-ORCS; 27146; 8 hits in 1062 CRISPR screens.
DR ChiTaRS; FAM184B; human.
DR GenomeRNAi; 27146; -.
DR Pharos; Q9ULE4; Tdark.
DR PRO; PR:Q9ULE4; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9ULE4; protein.
DR Bgee; ENSG00000047662; Expressed in secondary oocyte and 114 other tissues.
DR Genevisible; Q9ULE4; HS.
DR InterPro; IPR029605; FAM184.
DR InterPro; IPR039478; FAM184A/B_N.
DR InterPro; IPR029606; FAM184B.
DR PANTHER; PTHR18870; PTHR18870; 1.
DR PANTHER; PTHR18870:SF8; PTHR18870:SF8; 1.
DR Pfam; PF15665; FAM184; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..1060
FT /note="Protein FAM184B"
FT /id="PRO_0000320551"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 994..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 51..159
FT /evidence="ECO:0000255"
FT COILED 192..333
FT /evidence="ECO:0000255"
FT COILED 402..502
FT /evidence="ECO:0000255"
FT COILED 584..769
FT /evidence="ECO:0000255"
FT COILED 806..934
FT /evidence="ECO:0000255"
FT COMPBIAS 167..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 952
FT /note="N -> S (in dbSNP:rs16895365)"
FT /id="VAR_039202"
FT VARIANT 1042
FT /note="V -> A (in dbSNP:rs6825562)"
FT /evidence="ECO:0000269|PubMed:10574462"
FT /id="VAR_039203"
FT CONFLICT 299
FT /note="D -> H (in Ref. 1; BAA86590)"
FT /evidence="ECO:0000305"
FT CONFLICT 643
FT /note="R -> H (in Ref. 1; BAA86590)"
FT /evidence="ECO:0000305"
FT CONFLICT 784
FT /note="R -> W (in Ref. 1; BAA86590)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1060 AA; 121044 MW; 7D0C7E118A6C8515 CRC64;
MASALNSKIN PPGTCQGSKA DGGAGWRMDC DPQMHVKMCK KIAQLTKVIY ALNTRQDEAE
ASMEALREAH QEELQNAVAE TKARLLQEQG CAEEEALLQR IQALESALEL QKRLTEEALA
ESASCRLETK ERELRVEAEH AERVLTLSRE MLELKADYER RLQHLTSHEA TPQGRLPQES
PETKSEPGQG PEMQEVLLEV QRLRVENQQL SKDYARKAEE LQATYERENE AIRQAMQQSV
SQALWQWQEK ESDLRKNFQV QESALQAQVR KLEGDLEHRG RKISDLKKYA QKLKERIQDL
DVQLKEARQE NSELKGTAKK LGEKLAVAKD RMMLQECRGT QQTDAMKTEL VSENKVLREE
NDLEAGNLHP QQDQSCLKEC PCMKGGTDMQ TKKEASAETE YMKQQYEEDL RKIKHQTEEE
KKHLKDQLVK RLEDLVKKHT VEIKSVRSSV EAERKKLQRE VEAQLEEVRK KSEKEIKQLE
EEKAALNVKL QNSLLEVLRL EEFIQQNKTR PTGAEESPQE LGRQHCSILE TQDPCLKLDE
TSPRGEEYQD KLAAEEGTSS DEEERTKVLL KEGSDPQPPL GSLLKEKTSK IQRLEEDWQS
QKAKLQAQVS QMQQALEQCT SNYREDLQAL KQLSDLEREK LQRELQETTQ QNHAMKAQLE
ASHQRALRML EKARHQELKA TEERLKKESS HSLQIQHQTH RLELQALEEK ARQELQEERE
RMQAQQALLL ESLRQELSEQ QAACSGHQKD LEALQAELRA LGRQQASSQC PGDSKDHIIA
TEERGGPGQA GSPPGAAGQG SGEGCGLWEE NAQLQDAVRR LRAEVEQHQQ EAQKLRDQRR
FLEETQQAQR AREVETLRQE HRKEMQAMVA DFSSAQAQLQ ARLAALEAEL KDSGEKPGKG
ASRPEDLQLI GRLQTRLKER EDIIKQLTEE RRFHYAAFPS AMSHRNRSFS FNPHPGYLTP
SMKKKKVEDV PSRVVSVPNL ASYAKNFLSG DLSSRINAPP ITTSPSLDPS PSCGRTYKPN
QSTDAKTATR TPDGETAQAK EVQQKQGSPH QEWFTKYFSF
