F184B_MOUSE
ID F184B_MOUSE Reviewed; 942 AA.
AC Q0KK56; Q0KK51; Q76KB4; Q7TNB6; Q9JJG2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Protein FAM184B;
GN Name=Fam184b; Synonyms=Kiaa1276; ORFNames=MNCb-2622;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE [GENOMIC
RP DNA] OF 50-458.
RC STRAIN=BALB/cCrSlc; TISSUE=Brain;
RX PubMed=16807365; DOI=10.1096/fj.06-5952fje;
RA Nakayama M., Iida M., Koseki H., Ohara O.;
RT "A gene-targeting approach for functional characterization of KIAA genes
RT encoding extremely large proteins.";
RL FASEB J. 20:1718-1720(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-942 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12465718; DOI=10.1093/dnares/9.5.179;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: I.
RT The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 9:179-188(2002).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0KK56-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0KK56-2; Sequence=VSP_031654, VSP_031655;
CC -!- SIMILARITY: Belongs to the FAM184 family. {ECO:0000305}.
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DR EMBL; AB257856; BAF03199.1; -; mRNA.
DR EMBL; AB257861; BAF03204.1; -; Genomic_DNA.
DR EMBL; AB041544; BAA95029.1; -; mRNA.
DR EMBL; BC056379; AAH56379.1; -; mRNA.
DR EMBL; AB093291; BAD02840.1; -; mRNA.
DR CCDS; CCDS19276.1; -. [Q0KK56-1]
DR RefSeq; NP_067391.3; NM_021416.3. [Q0KK56-1]
DR AlphaFoldDB; Q0KK56; -.
DR SMR; Q0KK56; -.
DR IntAct; Q0KK56; 1.
DR STRING; 10090.ENSMUSP00000016023; -.
DR iPTMnet; Q0KK56; -.
DR PhosphoSitePlus; Q0KK56; -.
DR MaxQB; Q0KK56; -.
DR PaxDb; Q0KK56; -.
DR PRIDE; Q0KK56; -.
DR ProteomicsDB; 275982; -. [Q0KK56-1]
DR ProteomicsDB; 275983; -. [Q0KK56-2]
DR Antibodypedia; 23092; 27 antibodies from 8 providers.
DR Ensembl; ENSMUST00000016023; ENSMUSP00000016023; ENSMUSG00000015879. [Q0KK56-1]
DR GeneID; 58227; -.
DR KEGG; mmu:58227; -.
DR UCSC; uc008xja.2; mouse. [Q0KK56-1]
DR UCSC; uc008xjb.2; mouse. [Q0KK56-2]
DR CTD; 27146; -.
DR MGI; MGI:2442958; Fam184b.
DR VEuPathDB; HostDB:ENSMUSG00000015879; -.
DR eggNOG; ENOG502RRRX; Eukaryota.
DR GeneTree; ENSGT00530000063669; -.
DR HOGENOM; CLU_005374_0_0_1; -.
DR InParanoid; Q0KK56; -.
DR OMA; PQELDCQ; -.
DR OrthoDB; 170922at2759; -.
DR PhylomeDB; Q0KK56; -.
DR TreeFam; TF316006; -.
DR BioGRID-ORCS; 58227; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q0KK56; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q0KK56; protein.
DR Bgee; ENSMUSG00000015879; Expressed in telencephalon lateral wall and 96 other tissues.
DR Genevisible; Q0KK56; MM.
DR InterPro; IPR029605; FAM184.
DR InterPro; IPR039478; FAM184A/B_N.
DR InterPro; IPR029606; FAM184B.
DR PANTHER; PTHR18870; PTHR18870; 3.
DR PANTHER; PTHR18870:SF8; PTHR18870:SF8; 3.
DR Pfam; PF15665; FAM184; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..942
FT /note="Protein FAM184B"
FT /id="PRO_0000320552"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 89..150
FT /evidence="ECO:0000255"
FT COILED 196..337
FT /evidence="ECO:0000255"
FT COILED 387..495
FT /evidence="ECO:0000255"
FT COILED 575..619
FT /evidence="ECO:0000255"
FT COILED 686..815
FT /evidence="ECO:0000255"
FT COMPBIAS 499..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 570..596
FT /note="AAECLNKDSTDSLQAHLLELQALEDNA -> VDGQLWIEYISPFTKCNCASY
FT RYPRKT (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_031654"
FT VAR_SEQ 597..942
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_031655"
FT CONFLICT 577
FT /note="D -> Y (in Ref. 3; AAH56379)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 942 AA; 107601 MW; A227CE846332BB5A CRC64;
MASALNSKIH PPGTCASSKA DARGGSGWRM DCDPEMHVKM CKKIAQLTKV IYALNTRQDE
VEVSVESIRE AHQEDLQDTG AETRTRLPQE QSRTSEDAET LLKRIQTLEN ALELQKRLTQ
EALAESASCK LETKERELRV EAEHAERVLI LSKEMLELKA DYEKRLQLLT SHEGPQWGQL
SQESPDATAE SSQRPEMHQV LLEVERLRAE NKQLSQDYAR KAEELQATYE RENEAIRQAM
QQSVSEALWQ WQEKESGLRK NFQVQESALQ AQVRKLEGDL EHRGRKISDL KKYAQKLKER
IQDLDVQLRE ARQENSELKS TARKLGEKLA IAKDRLMLQE CHVTQKTDDM KTEDGVLGKR
DDLEACSLHP QQEQGFPKLC HCRNGGSETQ TKKEASGEME NMKQQYEEDL RKVRHQTEEE
KQQLREQLGK RLEDLVKKHT MEMKSVCSTV EVERKKLKEV EAQLEEVKTK SEREIQQLQE
EKAALSTKLQ NSLLEDPCSR PKKPARDEGL EKLTDEEESS SDEEERTGES VKGKSDLQPP
FESVMKEKAV EIGHRPEDWQ SQRTKLQTQA AECLNKDSTD SLQAHLLELQ ALEDNARQEL
QEDCEQMQVQ QSGLLESLRQ ELTEQRVACC EHQKALEMLQ NEFRAVGPLG KWQATNQCPG
DRRDHTFITE DMGVTGPPGS LPCAAEKGLL EENAQLQDTV LRLRAEVDQH LQEALQLREQ
HRLLEEDQKA QRAMEVEALR QEHRKEMQAM VADFSGAQAR LQARLAALET ELKESGEKAG
KGTSRPEDLQ LIGRLQTRLK EREDIIRQLT EERRFHYAAF PSAVSHRNRS FSFNPHPGYL
TPSMKKKKME EVPSRVVSVP NLASYAKNFL SGDLSSRINA PPITKSPSLD PSPSCSQPYK
PTQLLDGKTA SRTQDGEPAQ PKEAPQKQGS PHQEWFTKYF SF
