F185A_MOUSE
ID F185A_MOUSE Reviewed; 378 AA.
AC Q7TPD2; Q8C6A4;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Protein FAM185A;
GN Name=Fam185a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7TPD2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7TPD2-2; Sequence=VSP_031805, VSP_031806;
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DR EMBL; AK076256; BAC36277.1; -; mRNA.
DR EMBL; BC055342; AAH55342.1; -; mRNA.
DR CCDS; CCDS39022.1; -. [Q7TPD2-1]
DR RefSeq; NP_808537.2; NM_177869.4. [Q7TPD2-1]
DR AlphaFoldDB; Q7TPD2; -.
DR STRING; 10090.ENSMUSP00000058333; -.
DR PhosphoSitePlus; Q7TPD2; -.
DR EPD; Q7TPD2; -.
DR MaxQB; Q7TPD2; -.
DR PaxDb; Q7TPD2; -.
DR PeptideAtlas; Q7TPD2; -.
DR PRIDE; Q7TPD2; -.
DR ProteomicsDB; 275984; -. [Q7TPD2-1]
DR ProteomicsDB; 275985; -. [Q7TPD2-2]
DR Antibodypedia; 31132; 41 antibodies from 17 providers.
DR DNASU; 330050; -.
DR Ensembl; ENSMUST00000056045; ENSMUSP00000058333; ENSMUSG00000047221. [Q7TPD2-1]
DR GeneID; 330050; -.
DR KEGG; mmu:330050; -.
DR UCSC; uc008won.2; mouse. [Q7TPD2-2]
DR UCSC; uc008woo.2; mouse. [Q7TPD2-1]
DR CTD; 222234; -.
DR MGI; MGI:2140983; Fam185a.
DR VEuPathDB; HostDB:ENSMUSG00000047221; -.
DR eggNOG; ENOG502QQG7; Eukaryota.
DR GeneTree; ENSGT00390000016680; -.
DR HOGENOM; CLU_072473_0_0_1; -.
DR InParanoid; Q7TPD2; -.
DR OMA; KTQSWFE; -.
DR OrthoDB; 1154103at2759; -.
DR PhylomeDB; Q7TPD2; -.
DR TreeFam; TF323809; -.
DR BioGRID-ORCS; 330050; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q7TPD2; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q7TPD2; protein.
DR Bgee; ENSMUSG00000047221; Expressed in animal zygote and 173 other tissues.
DR Genevisible; Q7TPD2; MM.
DR InterPro; IPR025164; DUF4097.
DR Pfam; PF13349; DUF4097; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..378
FT /note="Protein FAM185A"
FT /id="PRO_0000321831"
FT VAR_SEQ 205..211
FT /note="TVSIEKL -> VRLKCS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031805"
FT VAR_SEQ 212..378
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031806"
FT CONFLICT 127
FT /note="S -> W (in Ref. 1; BAC36277)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 378 AA; 39992 MW; 192F6C3C890A8F10 CRC64;
MFGRLPPCAS RVRAGALVGA LGARTCGSSG AQRQGSAPDD SGAGLARGAL REWTLQVSPF
GRLRARLPCH LAVRPLDPLA HPDGDRVQVA VCGVEHVARG LDSLQVKYDA DRQEMAILSD
DIDPQASVEV NAPVKFDLSI ESSGSGSVKV QNIECDSCKI DTEQGTSILQ SVKSQKLHVQ
TKGGDVICCG TVYGNIDIHA SDKSTVSIEK LQGSCVNIST EDGLLQAKYL YTESSFLSSA
AGNIALGNVH GNIILQSKMG NITVDSSCGC LKASSHQGAI DVYVSQLGEV ALTTEEGSIA
VKAPSSLRAY FKLSGKEVVV DEEAHVQEMA KDCKGDGVTV TGLMNQASKH ERWINAIAPK
GTVSFQHQSW FQSLKLPD
