F186A_HUMAN
ID F186A_HUMAN Reviewed; 2351 AA.
AC A6NE01;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 3.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Protein FAM186A;
GN Name=FAM186A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1063, AND VARIANT GLN-187.
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2218-2351, AND VARIANT GLN-2228.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the FAM186 family. {ECO:0000305}.
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DR EMBL; AC090058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC140061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL833333; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BX099768; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS44878.1; -.
DR RefSeq; NP_001138947.1; NM_001145475.1.
DR AlphaFoldDB; A6NE01; -.
DR SMR; A6NE01; -.
DR BioGRID; 125703; 2.
DR IntAct; A6NE01; 4.
DR MINT; A6NE01; -.
DR STRING; 9606.ENSP00000329995; -.
DR iPTMnet; A6NE01; -.
DR PhosphoSitePlus; A6NE01; -.
DR BioMuta; FAM186A; -.
DR EPD; A6NE01; -.
DR jPOST; A6NE01; -.
DR MassIVE; A6NE01; -.
DR PaxDb; A6NE01; -.
DR PeptideAtlas; A6NE01; -.
DR PRIDE; A6NE01; -.
DR ProteomicsDB; 951; -.
DR Antibodypedia; 49485; 7 antibodies from 6 providers.
DR DNASU; 121006; -.
DR Ensembl; ENST00000327337.6; ENSP00000329995.5; ENSG00000185958.10.
DR GeneID; 121006; -.
DR KEGG; hsa:121006; -.
DR MANE-Select; ENST00000327337.6; ENSP00000329995.5; NM_001145475.3; NP_001138947.1.
DR UCSC; uc001rwl.3; human.
DR CTD; 121006; -.
DR DisGeNET; 121006; -.
DR GeneCards; FAM186A; -.
DR HGNC; HGNC:26980; FAM186A.
DR HPA; ENSG00000185958; Tissue enriched (testis).
DR neXtProt; NX_A6NE01; -.
DR OpenTargets; ENSG00000185958; -.
DR PharmGKB; PA164719869; -.
DR VEuPathDB; HostDB:ENSG00000185958; -.
DR eggNOG; ENOG502S707; Eukaryota.
DR GeneTree; ENSGT00940000163376; -.
DR HOGENOM; CLU_232743_0_0_1; -.
DR InParanoid; A6NE01; -.
DR OMA; KEVQWSH; -.
DR OrthoDB; 45971at2759; -.
DR PhylomeDB; A6NE01; -.
DR TreeFam; TF338344; -.
DR PathwayCommons; A6NE01; -.
DR SignaLink; A6NE01; -.
DR BioGRID-ORCS; 121006; 9 hits in 1063 CRISPR screens.
DR ChiTaRS; FAM186A; human.
DR GenomeRNAi; 121006; -.
DR Pharos; A6NE01; Tdark.
DR PRO; PR:A6NE01; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; A6NE01; protein.
DR Bgee; ENSG00000185958; Expressed in right testis and 78 other tissues.
DR ExpressionAtlas; A6NE01; baseline and differential.
DR Genevisible; A6NE01; HS.
DR InterPro; IPR039332; FAM186A.
DR PANTHER; PTHR33590:SF2; PTHR33590:SF2; 8.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..2351
FT /note="Protein FAM186A"
FT /id="PRO_0000332201"
FT REGION 412..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1805..1837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1888..1907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 296..340
FT /evidence="ECO:0000255"
FT COILED 812..860
FT /evidence="ECO:0000255"
FT COMPBIAS 412..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..635
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 809..826
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..922
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1815..1837
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 187
FT /note="K -> Q (in dbSNP:rs12303082)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_054419"
FT VARIANT 1204
FT /note="R -> G (in dbSNP:rs10876024)"
FT /id="VAR_054420"
FT VARIANT 1233
FT /note="L -> P (in dbSNP:rs10876023)"
FT /id="VAR_054421"
FT VARIANT 2166
FT /note="H -> Y (in dbSNP:rs7296291)"
FT /id="VAR_054422"
FT VARIANT 2193
FT /note="M -> I (in dbSNP:rs6580742)"
FT /id="VAR_054423"
FT VARIANT 2228
FT /note="H -> Q (in dbSNP:rs6580741)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_054424"
FT VARIANT 2316
FT /note="Q -> E (in dbSNP:rs12809349)"
FT /id="VAR_054425"
FT CONFLICT 165
FT /note="T -> M (in Ref. 2; AL833333)"
FT /evidence="ECO:0000305"
FT CONFLICT 463..465
FT /note="KKA -> TKG (in Ref. 2; AL833333)"
FT /evidence="ECO:0000305"
FT CONFLICT 935
FT /note="Q -> R (in Ref. 2; AL833333)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2351 AA; 262758 MW; 290E59F3CC9085B4 CRC64;
MFFKMKNEID NDPESEKCIK DSTIMRREPQ NILSPLMLPN LEIPFSVKDI ISRIERAQLH
RAREDIDMQL SEIMNNVHRI MTRYTLVFNS SSERNVSLTE HKKKQRTNFL EKMATYAKTI
EIREKTLANI LAWLEEWNDV LSEMTLMDVD EHHHWIAQME LLPDTLKAIE NNVKILSRFS
TSFLDEKKKQ KKKILSRGTL WKSWKERVIK RPSTARALRP DQMISDQLAT NTKVSEIQGM
LQELIGTTMF STLENNAIKY ISSTIVNLST ALSMLNDELK CVNFQSSTVY AHETSEAEKE
LSLKIIRDLS NENEMLQQKL QDAEEKCEQL IRSKIVIEQL YAKLSTSSTL KVLPGPSPQS
SRAIIKVGDT EDNMDNILDK ELENIVDEVQ RKETKDSGIK WDSTISYTAQ AERTPDLTEL
RQQPVASEDI SEDSTKDNVS LKKGDFYQED ETDEYQSWKR SHKKATYVYE TSGPNLSDNK
SGQKVSEAKP SQYYELQVLK KKRKEMKSFS EDKSKSPTEA KRKHLSLTET KSQGGKSGTS
MMMLEQFRKV KRESPFDKRP TAAEIKVEPT TESLDKEGKG EIRSLVEPLS MIQFDDTAEP
QKGKIKGKKH HISSGTITSK EEKTEEKEEL TKQVKSHQLV KSLSRVAKET SESTRVLESP
DGKSEQSNLE EFQEAIMAFL KQKIDNIGKA FDKKTVPKEE ELLKRAEAEK LGIIKAKMEE
YFQKVAETVT KILRKYKDTK KEEQVGEKPI KQKKVVSFMP GLHFQKSPIS AKSESSTLLS
YESTDPVINN LIQMILAEIE SERDIPTVST VQKDHKEKEK QRQEQYLQEG QEQMSGMSLK
QQLLGERNLL KEHYEKISEN WEEKKAWLQM KEGKQEQQSQ KQWQEEEMWK EEQKQATPKQ
AEQEEKQKQR GQEEEELPKS SLQRLEEGTQ KMKTQGLLLE KENGQMRQIQ KEAKHLGPHR
RREKGKEKQK PERGLEDLER QIKTKDQMQM KETQPKELEK MVIQTPMTLS PRWKSVLKDV
QRSYEGKEFQ RNLKTLENLP DEKEPISITP PPSLQYSLPG ALPISGQPLT KCIHLTPQQA
QEVGITLTPQ QAQAQGITLT LQQAQELGIP LTPQQAQALE ILFTPQQAQA LGIPLTPQQT
QVQGITLTPQ QDQAPGISLT TQQAQKLGIP LTPQQAQALG IPLTPQQAQE LGIPLTPQQA
QALRVSLTPQ QAQELGIPLT PQQAQALGIT LTLQQAQQLG IPLTPQQAQA LGITLTPKQV
QELGIPLTPQ QAQALGITLT PKQAQELGIP LNPQQAQTLG IPLTPKQAQA LGIPFTPQQA
QALGIPLTPQ QAQTQEITLT PQQAQALGMP LTTQQAQELG IPLTPQHAQA LGMPLTTQQA
QELGIPLTPQ QAQALGMPLT TQQAQELGIP LTPQQAQELG IPFTPQQAQA QEITLTPQQA
QALGMPLTAQ QAQELGITLT PQQAQELGIP LTPQQAQALG IPLIPPQAQE LGIPLTPQQA
QALGILLIPP QAQELGIPLT PQQAQALGIP LIPPQAQELG IPLTPQQVQA LGIPLIPPQA
QELEIPLTPQ QAQALGIPLT PQQAQELGIP LTPQQAQELG IPLTPQQAQA QGIPLTPQQA
QALGISLTPQ QAQAQGITLT PQQAQALGVP ITPVNAWVSA VTLTSEQTHA LESPMNLEQA
QEQLLKLGVP LTLDKAHTLG SPLTLKQVQW SHRPFQKSKA SLPTGQSIIS RLSPSLRLSL
ASSAPTAEKS SIFGVSSTPL QISRVPLNQG PFAPGKPLEM GILSEPGKLG APQTLRSSGQ
TLVYGGQSTS AQFPAPQAPP SPGQLPISRA PPTPGQPFIA GVPPTSGQIP SLWAPLSPGQ
PLVPEASSIP GDLLESGPLT FSEQLQEFQP PATAEQSPYL QAPSTPGQHL ATWTLPGRAS
SLWIPPTSRH PPTLWPSPAP GKPQKSWSPS VAKKRLAIIS SLKSKSVLIH PSAPDFKVAQ
VPFTTKKFQM SEVSDTSEET QILRDTFAIE SFRTFQSHFT KYRTPVYQTP YTDERALLTL
MKPTTSPSSL TTLLRTSQIS PLEWYQKSRF PPIDKPWILS SVSDTKKPKV MVPPSSPQEL
EEKRYFVDVE AQKKNLILLN QAIKTCGLPS QLHTMARTLI IEILHMDTVQ LGYLFRKYIA
YRLIQHARNN IMKRLKAIQN TGKGYEARNL HMMLSRLDDY GKKVMQVWTE KQKSLGQKRN
QCLKKMIHVF NQLKKIHELN LSQPIPLIIE EKQIPASTTF VQKPFLKLLM EEDRTSDICK
KFRQQEDQTE AIWNVDLSTS SYPIAEKTSM HSLWAQLGGY PDIPRLLQLE VQSTFRKSLA
SLQSRVKKIP K
