F186A_MOUSE
ID F186A_MOUSE Reviewed; 1790 AA.
AC Q9D9R9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Protein FAM186A;
GN Name=FAM186A; Synonyms=Gm920;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D9R9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D9R9-2; Sequence=VSP_036417;
CC -!- SIMILARITY: Belongs to the FAM186 family. {ECO:0000305}.
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DR EMBL; AK006542; BAB24644.1; -; mRNA.
DR EMBL; AC138177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC048613; AAH48613.1; -; mRNA.
DR CCDS; CCDS37207.1; -. [Q9D9R9-2]
DR RefSeq; NP_082456.1; NM_028180.3. [Q9D9R9-2]
DR AlphaFoldDB; Q9D9R9; -.
DR SMR; Q9D9R9; -.
DR IntAct; Q9D9R9; 1.
DR STRING; 10090.ENSMUSP00000053434; -.
DR PhosphoSitePlus; Q9D9R9; -.
DR PaxDb; Q9D9R9; -.
DR PRIDE; Q9D9R9; -.
DR ProteomicsDB; 275718; -. [Q9D9R9-1]
DR Antibodypedia; 49485; 7 antibodies from 6 providers.
DR DNASU; 72277; -.
DR Ensembl; ENSMUST00000062631; ENSMUSP00000053434; ENSMUSG00000045350. [Q9D9R9-2]
DR GeneID; 72277; -.
DR KEGG; mmu:72277; -.
DR UCSC; uc007xqj.2; mouse. [Q9D9R9-2]
DR CTD; 121006; -.
DR MGI; MGI:2685766; Fam186a.
DR VEuPathDB; HostDB:ENSMUSG00000045350; -.
DR eggNOG; ENOG502S707; Eukaryota.
DR GeneTree; ENSGT00940000163376; -.
DR HOGENOM; CLU_2020593_0_0_1; -.
DR InParanoid; Q9D9R9; -.
DR OrthoDB; 45971at2759; -.
DR BioGRID-ORCS; 72277; 2 hits in 37 CRISPR screens.
DR ChiTaRS; Fam186a; mouse.
DR PRO; PR:Q9D9R9; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9D9R9; protein.
DR Bgee; ENSMUSG00000045350; Expressed in spermatid and 10 other tissues.
DR ExpressionAtlas; Q9D9R9; baseline and differential.
DR Genevisible; Q9D9R9; MM.
DR InterPro; IPR039332; FAM186A.
DR PANTHER; PTHR33590:SF2; PTHR33590:SF2; 20.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..1790
FT /note="Protein FAM186A"
FT /id="PRO_0000332202"
FT VAR_SEQ 1..1686
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_036417"
SQ SEQUENCE 1790 AA; 194550 MW; CC80B2BB43A651B9 CRC64;
MPVKRQSKVY YESDSDDDDD EFKELATLRK PISNRDNPLS LQFEIPASVQ SVIHKIEESH
IFRAKEEVIW RLTEIMSNVE LIMTRYNIDS MSPGRKGSSS ESQKKKRKAF LEKIATVMTN
VDLRERTLSK ILSWLEEWNL ILSEVSAINM DDYYHWTVKM ELIPDTLKRI SKNVDSLIQM
ALLLVEEKKR AKKRILARGT LWKAWKDRAI KRPATAQALR LDQMIFDQIG LNAKVSEIQG
MLQELIGTAM FSKLENTAIK YMSTTVINLS KALNTVSDEL KLARALGVTL TPEQYKEDRI
SLTPLQAQVL GITLNLQQAK ALGITLTPEQ VKAQRVNLIP QQYQVHGTTL TTQQAEAQRT
NLTPEQAKAL GLPLIPPKPI TFTREQTQAL GITPTHQPIT LTSEQVQALG ITPTHQPITL
TPEQAQALAL ILTTEQVKTQ RINLSPDQTQ ALGITPTPQP ITFTPEQTQA LGITPTPQLI
TLTPEQAKAL ANTLTAEQVS LSPQQAEALG ITPTPQPTTL TPEQAQALGI TPTPQPITLT
PEQVQALGIT PNRESITLSP EQAQALGITP TPQPTTLTPE QTQALGITPT PQPITLTPEQ
AQALGITPTP QPITLTPEQT QALGITPTPQ PITLTPEQAQ ALGITPTPQP ITLTPEQTQA
LGITPTPQPI TLTPEQAQAL GITPTPQPIT LTPEQAQALG ITPTPQPITL TPEQAQALGI
TPTPQPITLT PEQTQALGIT PTPQPITLTP EQAQALGITP TPQPITLTPE QVQALGITPT
PQPITLTPEQ AQALGITPTP QPITLTPEQA QALGITPTPQ PITLTPEQTQ ALGITPTPQP
ITLTPEQAQA LGITPTPQPI TLTPELVQAL GITPTPQPIT LTPEQAQALG ITPTPQPTTL
SPEQAQALGI TPTPQPITLT PEQAQALGIT PTPQPTTLSP EQAQALGISL IPKQQEISLS
PEQAQALGLT LTPQQAQVQK IYLTPQQAQA LGITVSPEQA KAKGISLTPE EAHSLGIILT
VEQAKAKRIN LTPQQAQDLG LTLTPEQAQD LGISLIPKQE ISFSPLQAQA MGLTLTPQQA
QVQKIYLTPQ QAQALGITVS PEQAKGISLT PEEAHSLGII LTVEQAKAQR INLTPQQAQD
LGLTLTPEQA QDLGISLIPK QQEISFSPLQ AQAMGLTLTP QQAQVQKIYL TPQQAQALGI
TVSPEQAKGI SLTPEEAHSL GIILTVEQAK AQRINLTPQQ AQDLGITLTP EQAQDLGISL
IPKQQEISFS PLQAQAMGLT LTPQQAQVQK IYLTPQQAQA LGITVSPEQA KGISLTPEEA
HSLGIALTVE QAKAQRINLT PQQAQDLGLT LTPEQAQDLG IASTLKQAEA VGIIPTPTPE
PYQERRLSLT SEQVQALRTS FPTKETLSLG IYLTPKQAQY LGITLTASQA KVMKICLTPE
QAQALGITVT PKQAKARRTS LTPEQAQALG VILTPEQAQA HRITVTPEQA QALGIALTPE
QAHALGIALT PEQAQAQDKP WTPTPVSSTR EAKMIVSPTD QHPEDGYVVD VEAQRKNLVT
LNQAAQTSAL PAQYLTIAKN LIIELLHIDT VRLGYLSRKY VAYRLIQLAR NHLTKRVKTI
QNTGKGYEVQ SLYTMLDRID QYQKKVMHSW TDKQKQLEQR RKQCLRSMTQ FFSQLERGYK
LSLSQPMPSI PSFKKIPGFT KLQRPVLELL IDDSKRSDLF KTLGQASVEA VWNADLSTSS
YPIIEKAPMS ALWAQLGGYP DIPKLLQLDI QSTFRKSLAS IRSQSKKIRK
