ID   F187A_BOVIN             Reviewed;         421 AA.
AC   A7E3C4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Ig-like V-type domain-containing protein FAM187A;
DE   Flags: Precursor;
GN   Name=FAM187A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-395.
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FAM187 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI51800.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR   EMBL; AAFC03022803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC151799; AAI51800.1; ALT_SEQ; mRNA.
DR   RefSeq; XP_005195827.1; XM_005195770.3.
DR   RefSeq; XP_005221022.1; XM_005220965.3.
DR   AlphaFoldDB; A7E3C4; -.
DR   STRING; 9913.ENSBTAP00000017992; -.
DR   PaxDb; A7E3C4; -.
DR   Ensembl; ENSBTAT00000017992; ENSBTAP00000017992; ENSBTAG00000013532.
DR   GeneID; 614821; -.
DR   KEGG; bta:614821; -.
DR   CTD; 100528020; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013532; -.
DR   VGNC; VGNC:55829; FAM187A.
DR   eggNOG; ENOG502QRCU; Eukaryota.
DR   GeneTree; ENSGT00530000063991; -.
DR   HOGENOM; CLU_054403_0_0_1; -.
DR   InParanoid; A7E3C4; -.
DR   OMA; IFTTFWE; -.
DR   OrthoDB; 1171180at2759; -.
DR   TreeFam; TF332178; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000013532; Expressed in midbrain and 36 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR039311; FAM187A/B.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR32178; PTHR32178; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..421
FT                   /note="Ig-like V-type domain-containing protein FAM187A"
FT                   /id="PRO_0000340653"
FT   TOPO_DOM        19..377
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        399..421
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          268..362
FT                   /note="Ig-like V-type"
FT   CARBOHYD        318
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        290..346
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   CONFLICT        134
FT                   /note="F -> L (in Ref. 2; AAI51800)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        381
FT                   /note="L -> I (in Ref. 2; AAI51800)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   421 AA;  48434 MW;  C30D00AF71FB2AA7 CRC64;
     MNLAHTTVLL WAWGSLQAFE IVEKENIFQR TPCPAFLMFD NAAYLTDMSF ELPCPCKPEE
     VSAVVWYYQK HLGSSHTKVL TDFDGRVLTE AAQVRVGSDM LVRFSIRMFS LLVFRAQPED
     SGLYFCGTRK GDYFYAYDVD IQSSEGMVAT FKDQGQEPLE DEYHGSLRVF TTFWEWTPCD
     RCGVRGEQWR IGLCYLQSPD LSPRYRKILP NVVSCGSRAV PRQLRAKASD HNPELLVRSC
     LMPCEKKKKV QEGVMAIFNY VSKVGSRPWL PQVPIQFHQQ RLGHGLIISC PGARPEHAVA
     WDKDHQYLYR TQYLKGVNGS MRVFIDHGNH LHIRFTQLED RGIYYCWRQG ERIAGFRLGV
     TSPGRYPVSF SDPETRAALG LILIGYMLIT VIFISIHLCR CCCYLFRFCP NFSPRLSRPQ
     L